Critical & Organ Care · 1968
Harvard Criteria for Brain Death
A Definition of Irreversible Coma: Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death
By the mid-1960s, the widespread adoption of mechanical ventilation in intensive care units had created a clinical situation that medicine's existing legal and ethical frameworks could not resolve. Patients who had sustained catastrophic brain injuries, with complete and permanent cessation of all brain function, could be maintained indefinitely on ventilators with intact circulation and warm skin. The traditional definition of death, cessation of heartbeat and respiration, no longer captured the biological reality of these cases, and clinicians faced the uncomfortable position of either continuing futile treatment or acting without any formal framework for declaring death.
Henry Beecher, an anesthesiologist at Harvard Medical School, had been thinking about this problem both clinically and ethically for several years. In 1967 he convened an ad hoc committee of physicians, lawyers, theologians, and a historian of science to produce a workable definition. The committee's report was published in JAMA in August 1968. The criteria they specified required unreceptivity and unresponsivity, no spontaneous movement or spontaneous breathing, absence of reflexes including pupillary and corneal responses, and a flat electroencephalogram, all confirmed on two examinations at least 24 hours apart after excluding hypothermia and central nervous system depressant drugs.
The committee was candid about one of its motivations. The report noted explicitly that patients meeting these criteria were a burden on other patients and on hospital resources, and that their organs might be used to help others if death could be declared. Joseph Murray, the transplant surgeon who had performed the first successful kidney transplant in 1954, was among the committee's members, and the need for a legally defensible moment of death before organ retrieval was part of the practical context the criteria were designed to address.
Reception was not uniform. Some neurologists and intensivists debated whether a 24-hour observation period was necessary in all cases, and whether EEG confirmation added to the clinical examination or was redundant. The criteria also applied only to total brain failure, not to the separate and more contentious question of patients in persistent vegetative states, which the Harvard criteria did not address. Nonetheless, the framework was adopted rapidly: most U.S. states enacted statutes incorporating neurological death over the following decade.
The Uniform Determination of Death Act of 1981 codified brain death alongside cardiopulmonary death in American law, and the criteria have been revised multiple times since 1968 in practice guidelines from the American Academy of Neurology, most recently in 2023. The core requirement of an irreversible, complete loss of all brain function, including the brainstem, confirmed by a structured clinical examination with specified preconditions excluded, remains in place.
Key People
- Henry Beecher — Harvard anesthesiologist who chaired the ad hoc committee defining irreversible coma.
- Joseph Murray — Transplant surgeon whose organ procurement needs helped motivate the criteria.
- Robert Schwab — Neurologist on the Harvard committee who contributed EEG expertise to the criteria.
JAMA. 1968;205(6):337-340.
Related landmarks
- 1971 · Naloxone approved as an opioid overdose antidote (Critical & Organ Care)
- 1975 · Extracorporeal membrane oxygenation (ECMO) for neonatal respiratory failure (Bartlett) (Critical & Organ Care)
- 1960 · Scribner shunt and long-term hemodialysis (Critical & Organ Care)
- 1980 · Exogenous surfactant therapy for neonatal respiratory distress syndrome (Fujiwara) (Critical & Organ Care)