New research and findings from open-access journals and the U.S. research agencies.
This cohort study compares postoperative pain outcomes and opioid consumption for hydrocodone vs oxycodone among CYP2D6 normal metabolizers undergoing elective joint arthroplasty.
This comparative effectiveness study assesses how treatment combinations, including platinum choice and bevacizumab use, are associated with overall survival and serious adverse events in patients with advanced cervical cancer.
This cohort study evaluates whether diagnosis-to-ablation time is associated with atrial arrhythmia recurrence following radiofrequency ablation for atrial fibrillation.
This comparative effectiveness trial compares the association of buprenorphine-naloxone vs extended-release (XR) naltrexone treatment with reduction of all-cause mortality and nonfatal opioid overdose among patients who completed medically managed opioid withdrawal.
GSK drug Jemperli met the main goal of a pivotal Phase 2 test in patients with a rare type of rectal cancer, paving the way for regulatory submissions. This antibody drug has already received a voucher to speed up its review under a new FDA pilot program. The post GSK Eyes FDA Filing After Immunotherapy Succeeds in Key Rectal Cancer Study appeared first on MedCity News .
The first vaccine against the Bundibugyo ebola virus is poised to enter phase 1 clinical trial.
Nearly 200 healthcare and patient advocacy organizations endorsed the bipartisan Clinical Trial Modernization Act, which seeks to reduce financial barriers and expand access to clinical trials for underrepresented patients. The post Nearly 200 Organizations Back Bill to Expand Access to Clinical Trials appeared first on MedCity News .
by Michael C. Thrun, Jörg Hoffmann, Stefan W. Krause, Peter Krawitz, Quirin Stier, Andreas Neubauer, Cornelia Brendel, Alfred Ultsch Background Multiparameter flow cytometry is a cornerstone of B cell non-Hodgkin lymphoma (B-NHL) diagnostics, but interpretation requires substantial expertise and is complicated by high-dimensional data, variable sample quality, limited data for rare entities, and evolving clinical classification systems. Current artificial intelligence approaches often require large training datasets and provide limited insight into the rationale behind individual diagnostic…
A total of 59% of clinical trial sites are seeing fewer eligible patients recruited due to inefficiencies with their recruitment process, according to a recent survey.
Objectives Local public health organisations require information about local variations in healthy life expectancy (HLE) and associated risks to inform decisions about how and where to intervene to improve HLE, a key indicator of population health. We aimed to estimate both HLE and levels of risk in small areas and quantify associations between them. Design Cross-sectional population-based study. Setting Norfolk and Waveney Integrated Care System. Population 128 Middle Layer Super Output Areas and eight Lower Tier Local Authority Areas. Outcome measures HLE (estimated using self-reported…
Introduction Sustainable procurement (SP) has emerged as an integral part of national and global efforts to address sustainable development challenges and the growing impact of climate change on human health, especially in resource-constrained health systems such as sub-Saharan Africa (SSA). We are conducting a scoping review to explore empirical studies on SP practices in SSA health systems, identify evidence gaps and inform future research directions. Methods and analysis The review will follow the JBI (Joanna Briggs Institute) methodology for scoping reviews and the Preferred Reporting…
Objective Antenatal care (ANC) visits play a vital role in protecting women’s health and their unborn babies. This study aimed to examine the associated factors with utilisation of ANC visits by using Andersen’s behavioural model based on predisposing, enabling and need factors. Design Cross-sectional study using secondary datasets from the Nepal Demographic and Health Survey 2016 and 2022 was appended for analysis. The analysis accounted for the stratified two-stage cluster sampling design of the survey by applying sampling weights and adjusting for clustering and stratification. A…
Introduction Trauma, obstetric haemorrhage and severe anaemia lead to millions of deaths every year. Many of these deaths occur in regions known as ‘blood deserts’ where there is virtually no access to blood transfusions. A community or civilian walking blood bank (CWBB) is a low-resource strategy that can provide just-in-time, point-of-care tested blood transfusions in blood deserts when banked blood is not readily available and the alternative is almost-certain death. This protocol is designed to evaluate the effectiveness and implementation of a CWBB at Lodwar County Referral Hospital…
Objective Antimicrobial resistance (AMR) is a global public health threat, responsible for an estimated 35 200 bacterial resistance attributable deaths in the UK in 2019. Social determinants of health (SDoH) drive inequities that influence health outcomes. We aimed to conduct a scoping review of the evidence of the association between the SDoH and AMR in the UK. Design A scoping review was conducted using search terms related to SDoH and AMR across multiple databases, supplemented by manual searches. This followed Arksey and O’Malley’s framework and the Preferred Reporting Items for Systematic…
Introduction Understanding population dynamics is essential for achieving the Sustainable Development Goals. Global population growth has slowed, and Iran has experienced a marked fertility decline. Given the decline in fertility rates and shifts in women’s attitudes and motivations regarding childbearing, this study aims to explore whether an artificial intelligence (AI)-based chatbot can improve attitudes and increase positive motivation towards childbearing among married women of reproductive age. Methods and analysis This parallel randomised controlled trial will be conducted on 80…
Introduction Early childhood obesity has become a major public health concern globally. The preschool period (ages 4–6 years) represents a critical window for obesity prevention due to its long-term implications on growth trajectories and behaviour formation. However, existing evidence for effective interventions targeting this age group remains limited and inconsistent, particularly in low- and middle-income countries. Methods and analysis The Peking University-Smart Monitoring and Responsive Technology for Early Childhood Health is a cluster-randomised controlled trial designed to evaluate…
Introduction Young men’s mental health is a continuing concern but remains underrepresented in both mental health services and research. Engaging young men in mental health research has proven difficult, but creative, strength-based and participatory methods may help overcome barriers and enhance understanding of how best to involve them. This study aims to explore young men’s perceptions of how healthcare and academic settings can better engage them in mental health research, and to examine whether participatory, strength-based approaches themselves foster greater engagement. Methods and…
Objectives To describe socio-demographic and health-related characteristics, eating behaviours, food satisfaction and oral health-related quality of life (OHRQoL) among community-dwelling older adults in Abha, Saudi Arabia; to assess how eating behaviours, food satisfaction and OHRQoL vary across socio-demographic and health-related groups; and to examine how eating behaviours and food satisfaction are associated with OHRQoL, adjusting for socio-demographic and health-related characteristics. Design A descriptive cross-sectional study. Setting Primary healthcare centres (PHCCs) in the Abha…
Introduction The clinical course of psoriasis is characterised by marked heterogeneity. Despite the availability of standardised assessment instruments, long-term outcomes at the individual level—encompassing the durability of treatment response, the risk of relapse and the development of comorbidities—remain difficult to predict. To address this uncertainty, numerous prognostic prediction models have been developed; however, their methodological quality, predictive performance and clinical applicability have not yet been systematically appraised. Methods and analysis A systematic search will…
Objectives To assess gender-related differences in patient-reported experiences across the cancer care pathway in Switzerland among patients with non-sex-specific cancers. Design Multicentre cross-sectional survey study. Setting Secondary and tertiary oncology care across 21 public and private hospitals in Switzerland, covering all linguistic regions. Participants Adult patients (≥18 years) with a confirmed diagnosis of cancer who received oncological care in participating centres and completed a standardised patient experience questionnaire. Of 4408 respondents included in the analysis…
Introduction Despite national efforts to improve research inclusion, people from underserved communities remain underrepresented in dementia trials. Barriers occur at the point of initial engagement and also within the participation pathway itself, as the structure and burden of early screening procedures can discourage continuation. ACCESS D (Advancing Community Collaboration and Engagement Strategies in Dementia) aims to address these challenges by testing a community-based model that combines co-produced engagement events, low-burden research participation, and real-time support from the…
Introduction This study aims to enhance aftercare for individuals with acquired brain injury (ABI), focusing on an active lifestyle and health-related quality of life, by implementing a multidisciplinary intervention using a network of outpatient rehabilitation and community-based services, and by evaluating its implementation process and outcomes. Methods and analysis The ABI-MOTION intervention includes 5 activities delivered through a network of outpatient rehabilitation and community-based services: outpatient rehabilitation, education flyer, introduction to a sports consultant, maximum of…
Introduction Climate change is intensifying extreme weather events and altering environmental conditions in ways that increasingly strain health systems. Prehospital emergency medical services (EMS), as the frontline interface between communities and acute care, are uniquely vulnerable to these pressures. Rising call volumes, infrastructure disruption, occupational heat and smoke exposure and service delays have been reported, yet the evidence remains fragmented across disciplines and regions. This scoping review aims to systematically map the global literature on climate-related hazards and…
Introduction Bipolar II disorder (BD-II) is characterised by hypomanic and depressive episodes with the latter tending to dominate the clinical course of the disorder, and they are often associated with suicidality. Despite available guideline-based recommendations for first-line pharmacological treatments, patient outcomes remain suboptimal, especially for those with chronic depression and suicidal ideation. The dearth of viable treatment options for this population is evident, which is where psychedelics propose an additional alternative path. Psilocybin has recently shown promise in…