Objectives The study aimed to explore why trauma and orthopaedic registrars decide to discontinue surgical training. Understanding the factors that influence a decision to leave may help to inform changes which enhance the experiences of surgeons and retention of the future workforce. Design Qualitative study using semi-structured interviews. Setting Between October 2022 and March 2026, interviews were conducted with participants who had left the UK National Health Service (NHS) trauma and orthopaedic specialty training before completion. Reflexive thematic analysis was performed on 1727 min…
Introduction Half of all patients with a hip fracture (HF) do not recover their pre-fracture mobility after 1 year. Mobility and functional capabilities may be impaired by postoperative low haemoglobin levels and iron deficiency. The primary objective of this trial is to compare the effect of a single postoperative dose of ferric derisomaltose 20 mg/kg body weight relative to placebo on the recovery of functional mobility in patients. Methods and analysis The IronHip trial is a multicentre, randomised, double-blind, placebo-controlled trial with participants allocated in a 1:1 ratio to receive…
The latest phase 2 readout for Q32 Bio’s alopecia hopeful received a warm reception from investors, supporting the biotech’s case that the drug could offer a more durable alternative to JAK inhibitors.
Background: Whether using both sodium–glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) is more effective than using either alone in type 2 diabetes mellitus remains uncertain. We sought to assess cardiovascular and kidney outcomes of combined SGLT2i and GLP-1RA therapy versus monotherapy using network meta-analysis. Methods: We identified randomized controlled trials (RCTs) of SGLT2i or GLP-1RA in patients with type 2 diabetes mellitus through a comprehensive search of MEDLINE, Embase, and the Cochrane Library until Aug. 15, 2025. We compared…
This prespecified secondary analysis of a randomized clinical trial assesses whether a multidomain lifestyle intervention, vs a self-guided program, alters trajectories of cerebrovascular magnetic resonance imaging (MRI) markers, whether baseline diffusion MRI estimates subsequent vascular injury, and whether any effects differ by age among adults 60 to 79 years of age who are at increased risk for cognitive decline.
This cross-sectional study reports on the implementation of a population-wide genomic screening program in South Carolina and assesses rates of screening for genetic disorders and positivity prevalence by rurality and social disadvantage.
This cross-sectional study explores whether coping strategies and social support are associated with readiness to transition to adult health care in young adults with sickle cell disease.
This cohort study uses a target trial emulation approach to evaluate neonatal outcomes for pregnancies with continuation of selective serotonin reuptake inhibitors (SSRIs) vs discontinuation.
This cohort study uses an emulated target trial design to evaluate the risk of hormone-related cancers after medically assisted reproductive treatment.
This case-control study evaluates the clinical utility of plasma phosphorylated tau 217 measures for identifying neuropathology among individuals at risk for chronic traumatic encephalopathy (CTE).
This cross-sectional study measures annual rates of vision screening at well-child care visits and the prevalence of vision loss–related conditions among American Indian or Alaska Native children in Minnesota.
This cohort study uses Danish registry data to examine the association of grandchild birthdays, as a proxy for opportunity for social gathering, with SARS-CoV-2 infection in grandparents.
This cohort study compares door-to-needle and door-in-door-out times between tenecteplase-treated and alteplase-treated patients with acute ischemic stroke in US hospitals.