Purpose The return to work after arthroplasty (REWARD) study was established to address knowledge gaps regarding factors influencing return to work and long-term workability following hip and knee arthroplasty. The study investigates how variables such as sex, occupational workload and prior treatments affect sick leave patterns across regions and healthcare providers in Sweden. By analysing trajectories of sick leave and disability pension before and after surgery, the study aims to identify determinants for successful return to work. Participants Initially, we identified two separate cohorts…
Introduction Surgical site infections (SSIs) impose a significant clinical and economic burden on the healthcare systems. To date, traditional preventive strategies have frequently failed to demonstrate definitive efficacy. Hypochlorous acid (HOCl) has emerged as a compelling antimicrobial alternative, characterised by potent microbicidal properties and excellent biocompatibility. Hypoclates:Peritonitis investigates the clinical impact of an HOCl-based lavage strategy in patients undergoing surgical treatment for secondary peritonitis. The trial evaluates the primary endpoint of postoperative…
Importance Day-of-surgery hyperglycaemia is a modifiable risk factor for adverse patient outcomes including infection and 30-day mortality. Despite these risks, important quality gaps in day-of-surgery glycaemic management have been demonstrated in multiple settings. Objective To describe barriers and facilitators to high-quality glycaemic management from the perspective of anaesthesiologists. Design This qualitative study was designed using two implementation frameworks, the Theoretical Domains Framework (TDF) and the Consolidated Framework for Implementation Research (CFIR), to understand…
The FDA now treats continuous, real-time data sharing as a regulatory direction of travel rather than a theoretical future. The neurology field should pay close attention. The post The Measurement Problem Behind Two Decades of Neurology Trial Failures appeared first on MedCity News .
Lower BMI in older patients undergoing TAVR was associated with higher risk of all-cause mortality and major cardiovascular and cerebrovascular events at one year; however, outcomes did not differ between BMI groups among patients younger than 65 years old, according to a study published July 10 in JACC: Advances.
Roche’s biggest bet in the Alzheimer’s disease space may be its phase 3-stage amyloid asset, but the Swiss pharma is keeping its options open when it comes to targeting tau.
The Original Investigation titled “Stage IV Breast Cancer Incidence and Survival, 2010-2021,” published on May 12, 2026, was corrected to fix errors in the Abstract Results. The data reported for increases in percentage of stage IV diagnoses in HR-positive/ERBB2-negative, HR-positive/ERBB2-positive, HR-negative/ERBB2-positive, and triple-negative breast cancer were incorrect. This article was corrected online.
This systematic review and meta-analysis examines whether people who smoke very low nicotine content cigarettes for extended periods compensate by increasing their smoking behavior and/or smoke exposure.
This cohort study examines whether diurnal salivary cortisol indices are associated with cognitive outcomes, including incident Alzheimer disease, and whether distributions and associations differ by race.
This cross-sectional study of children living in Ontario, Canada, examines the association between area-based deprivation and the incidence of childhood cancer in a setting with universal access to publicly funded health care.
This randomized clinical trial compares rates of late-onset sepsis among neonates cleansed daily with octenidine wipes compared with sterile water in a neonatal intensive care unit (NICU) in India.
This cohort study assesses the outcomes of rituximab-treated patients with immunodeficiency associated with anti–interferon-γ autoantibodies for as long as 4 years of posttreatment follow-up.
This case-control study evaluates the performance of magnetic resonance imaging (MRI)–based staging vs traditional digital rectal examination–based staging in men undergoing radical prostatectomy.
Brain-computer interface training, which uses feedback from electrical activity in the brain, shows promise in improving cognitive function in neuropsychiatric patients with Parkinson’s disease, multiple sclerosis, dementia and traumatic brain injury.
In the Original Investigation titled “Measurement-Based Care to Enhance Antidepressant Treatment Outcomes in Major Depressive Disorder: A Randomized Clinical Trial” published on September 2, 2025, the values for annual participant and household income and time since diagnosis (median and IQR) reported in Table 1 were calculated using the SPSS “HAVERAGE” (weighted average/interpolated) method, but should have been calculated using simple non-interpolated methods. The values have been recalculated accordingly and the article has been corrected.
This cross-sectional study investigates how menopause-related symptoms discussed in user-generated online posts compared with symptoms documented in electronic health record clinicial notes.
This cohort study examines the associations between childhood maltreatment and adult multimorbidity using electronic health records for individuals in Hong Kong.
This cohort study of insured US patients with colorectal cancer undergoing curative-intent surgery examines the association of delays in treatment with metastasis.
This cohort study evaluates which early-life health and socioeconomic factors are associated with school readiness and educational attainment among children aged 5 to 7 years born very preterm in the UK.