The latest headlines across every section, pulled from official and open-access sources.
Agenus has scrapped a phase 3 study of its combo therapy in colorectal cancer after just three months in order to go all-in on colon cancer.
Pharma platform company China Medical System Holdings has tapped up existing partner Insilico for a 1.2 billion yuan ($177 million) collaboration aimed at a “mass-market” central nervous system indication.
Background: Whether using both sodium–glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) is more effective than using either alone in type 2 diabetes mellitus remains uncertain. We sought to assess cardiovascular and kidney outcomes of combined SGLT2i and GLP-1RA therapy versus monotherapy using network meta-analysis. Methods: We identified randomized controlled trials (RCTs) of SGLT2i or GLP-1RA in patients with type 2 diabetes mellitus through a comprehensive search of MEDLINE, Embase, and the Cochrane Library until Aug. 15, 2025. We compared…
M. Scotch et al.
M. T. Yazdi et al.
N. Nowotny et al.
P. Bogovič et al.
The distal tip in certain lots of the Medtronic Harmony Delivery Catheter System (DCS) may detach which can require endovascular retrieval or surgical intervention.
A former Mayo Clinic research director claims she was silenced, demoted and ultimately fired for sounding the alarm on AI safety and patient privacy lapses at the health system. Traci Tamiko Eto is now suing Mayo for retaliation. The post Former Mayo Clinic Leader Sues System Over Alleged AI Cover-Up: 6 Things to Know appeared first on MedCity News .
CMS’s new GLP-1 Bridge program expands Medicare access to obesity drugs but raises concerns about cost, supply and implementation challenges. The post Does CMS Know What It Is Doing With Its GLP-1 Obesity Coverage Pilot? appeared first on MedCity News .
This prespecified secondary analysis of a randomized clinical trial assesses whether a multidomain lifestyle intervention, vs a self-guided program, alters trajectories of cerebrovascular magnetic resonance imaging (MRI) markers, whether baseline diffusion MRI estimates subsequent vascular injury, and whether any effects differ by age among adults 60 to 79 years of age who are at increased risk for cognitive decline.
Hematology
Genetics and Genomics
This cross-sectional study reports on the implementation of a population-wide genomic screening program in South Carolina and assesses rates of screening for genetic disorders and positivity prevalence by rurality and social disadvantage.
This cross-sectional study explores whether coping strategies and social support are associated with readiness to transition to adult health care in young adults with sickle cell disease.
This cohort study uses a target trial emulation approach to evaluate neonatal outcomes for pregnancies with continuation of selective serotonin reuptake inhibitors (SSRIs) vs discontinuation.