Objective Antimicrobial resistance (AMR) is a global public health threat, responsible for an estimated 35 200 bacterial resistance attributable deaths in the UK in 2019. Social determinants of health (SDoH) drive inequities that influence health outcomes. We aimed to conduct a scoping review of the evidence of the association between the SDoH and AMR in the UK. Design A scoping review was conducted using search terms related to SDoH and AMR across multiple databases, supplemented by manual searches. This followed Arksey and O’Malley’s framework and the Preferred Reporting Items for Systematic…
Introduction Understanding population dynamics is essential for achieving the Sustainable Development Goals. Global population growth has slowed, and Iran has experienced a marked fertility decline. Given the decline in fertility rates and shifts in women’s attitudes and motivations regarding childbearing, this study aims to explore whether an artificial intelligence (AI)-based chatbot can improve attitudes and increase positive motivation towards childbearing among married women of reproductive age. Methods and analysis This parallel randomised controlled trial will be conducted on 80…
Introduction Early childhood obesity has become a major public health concern globally. The preschool period (ages 4–6 years) represents a critical window for obesity prevention due to its long-term implications on growth trajectories and behaviour formation. However, existing evidence for effective interventions targeting this age group remains limited and inconsistent, particularly in low- and middle-income countries. Methods and analysis The Peking University-Smart Monitoring and Responsive Technology for Early Childhood Health is a cluster-randomised controlled trial designed to evaluate…
Introduction Young men’s mental health is a continuing concern but remains underrepresented in both mental health services and research. Engaging young men in mental health research has proven difficult, but creative, strength-based and participatory methods may help overcome barriers and enhance understanding of how best to involve them. This study aims to explore young men’s perceptions of how healthcare and academic settings can better engage them in mental health research, and to examine whether participatory, strength-based approaches themselves foster greater engagement. Methods and…
Objectives To describe socio-demographic and health-related characteristics, eating behaviours, food satisfaction and oral health-related quality of life (OHRQoL) among community-dwelling older adults in Abha, Saudi Arabia; to assess how eating behaviours, food satisfaction and OHRQoL vary across socio-demographic and health-related groups; and to examine how eating behaviours and food satisfaction are associated with OHRQoL, adjusting for socio-demographic and health-related characteristics. Design A descriptive cross-sectional study. Setting Primary healthcare centres (PHCCs) in the Abha…
Introduction The clinical course of psoriasis is characterised by marked heterogeneity. Despite the availability of standardised assessment instruments, long-term outcomes at the individual level—encompassing the durability of treatment response, the risk of relapse and the development of comorbidities—remain difficult to predict. To address this uncertainty, numerous prognostic prediction models have been developed; however, their methodological quality, predictive performance and clinical applicability have not yet been systematically appraised. Methods and analysis A systematic search will…
Objectives To assess gender-related differences in patient-reported experiences across the cancer care pathway in Switzerland among patients with non-sex-specific cancers. Design Multicentre cross-sectional survey study. Setting Secondary and tertiary oncology care across 21 public and private hospitals in Switzerland, covering all linguistic regions. Participants Adult patients (≥18 years) with a confirmed diagnosis of cancer who received oncological care in participating centres and completed a standardised patient experience questionnaire. Of 4408 respondents included in the analysis…
Introduction Despite national efforts to improve research inclusion, people from underserved communities remain underrepresented in dementia trials. Barriers occur at the point of initial engagement and also within the participation pathway itself, as the structure and burden of early screening procedures can discourage continuation. ACCESS D (Advancing Community Collaboration and Engagement Strategies in Dementia) aims to address these challenges by testing a community-based model that combines co-produced engagement events, low-burden research participation, and real-time support from the…
Introduction This study aims to enhance aftercare for individuals with acquired brain injury (ABI), focusing on an active lifestyle and health-related quality of life, by implementing a multidisciplinary intervention using a network of outpatient rehabilitation and community-based services, and by evaluating its implementation process and outcomes. Methods and analysis The ABI-MOTION intervention includes 5 activities delivered through a network of outpatient rehabilitation and community-based services: outpatient rehabilitation, education flyer, introduction to a sports consultant, maximum of…
Introduction Climate change is intensifying extreme weather events and altering environmental conditions in ways that increasingly strain health systems. Prehospital emergency medical services (EMS), as the frontline interface between communities and acute care, are uniquely vulnerable to these pressures. Rising call volumes, infrastructure disruption, occupational heat and smoke exposure and service delays have been reported, yet the evidence remains fragmented across disciplines and regions. This scoping review aims to systematically map the global literature on climate-related hazards and…
Introduction Bipolar II disorder (BD-II) is characterised by hypomanic and depressive episodes with the latter tending to dominate the clinical course of the disorder, and they are often associated with suicidality. Despite available guideline-based recommendations for first-line pharmacological treatments, patient outcomes remain suboptimal, especially for those with chronic depression and suicidal ideation. The dearth of viable treatment options for this population is evident, which is where psychedelics propose an additional alternative path. Psilocybin has recently shown promise in…
Objectives The study aimed to explore why trauma and orthopaedic registrars decide to discontinue surgical training. Understanding the factors that influence a decision to leave may help to inform changes which enhance the experiences of surgeons and retention of the future workforce. Design Qualitative study using semi-structured interviews. Setting Between October 2022 and March 2026, interviews were conducted with participants who had left the UK National Health Service (NHS) trauma and orthopaedic specialty training before completion. Reflexive thematic analysis was performed on 1727 min…
Introduction Half of all patients with a hip fracture (HF) do not recover their pre-fracture mobility after 1 year. Mobility and functional capabilities may be impaired by postoperative low haemoglobin levels and iron deficiency. The primary objective of this trial is to compare the effect of a single postoperative dose of ferric derisomaltose 20 mg/kg body weight relative to placebo on the recovery of functional mobility in patients. Methods and analysis The IronHip trial is a multicentre, randomised, double-blind, placebo-controlled trial with participants allocated in a 1:1 ratio to receive…
The latest phase 2 readout for Q32 Bio’s alopecia hopeful received a warm reception from investors, supporting the biotech’s case that the drug could offer a more durable alternative to JAK inhibitors.
The World Health Organization (WHO) has validated El Salvador as having eliminated trachoma as a public health problem. Trachoma is the world's leading infectious cause of blindness.
Republicans say California’s use of Medicaid money for social services amounts to waste, fraud, and abuse. But even as Gov. Gavin Newsom voices concern about losing funding, he says he’s proud of the state’s holistic approach to caring for its sickest and most expensive patients.
Pharma platform company China Medical System Holdings has tapped up existing partner Insilico for a 1.2 billion yuan ($177 million) collaboration aimed at a “mass-market” central nervous system indication.
Background: Whether using both sodium–glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) is more effective than using either alone in type 2 diabetes mellitus remains uncertain. We sought to assess cardiovascular and kidney outcomes of combined SGLT2i and GLP-1RA therapy versus monotherapy using network meta-analysis. Methods: We identified randomized controlled trials (RCTs) of SGLT2i or GLP-1RA in patients with type 2 diabetes mellitus through a comprehensive search of MEDLINE, Embase, and the Cochrane Library until Aug. 15, 2025. We compared…