Eli Lilly has struck a deal to buy AtaiBeckley for $2.8 billion upfront, continuing its takeover spree to move into a psychedelic mental health sector targeted by companies including Johnson & Johnson.
Objectives Low intervention uptake and contamination can dilute effects of cluster randomised trials (CRTs). We investigated the feasibility of digital fingerprints to assess intervention coverage and contamination in a CRT of community-based sexual and reproductive health services for youth (CHIEDZA). Methods 24 clusters in Zimbabwe were randomly allocated to intervention/control. In intervention clusters, CHIEDZA services were provided in community halls for 30 months. A population-based survey of youth aged 18–24 (700/cluster) was conducted to ascertain impact. Digital fingerprints were…
Introduction Canadian long-term care (LTC) homes have faced long-standing challenges with quality of care, staffing and resource limitations. In Ontario, specifically, there has been increased focus on resilience and performance in LTC homes given the burden that the COVID-19 pandemic presented (eg, highest number of resident deaths due to COVID-19 across Canada, staffing crisis). Nevertheless, little is known about the current practices and operational state of LTC homes in the province and limited data are collected on Ontario’s LTC homes at the organisational level and on the factors that…
Objective To determine the prevalence and factors associated with stress, anxiety and depression among married women in Chandrapur municipality, Nepal. Design We conducted a cross-sectional study. Setting Household Survey of Chandrapur municipality, Nepal. Participants We enrolled 545 married women from June to August 2022. Outcome measures We administered the Depression, Anxiety and Stress Scale (DASS-21) through face-to-face interviews to determine the prevalence of stress, anxiety and depression. We performed univariable and multivariable linear regression to identify factors associated…
Objectives This study aimed to assess the pooled proportion of dropout from the maternal continuum of care (CoC) and its associated factors in low-income and middle-income countries (LMICs). Study design Cross-sectional study using nationally representative demographic and health survey (DHS) data. Setting 41 LMICs with DHS data available after the establishment of the Sustainable Development Goals from 2016 to 2024 were included. A total of 217 083 (weighted 213 474) women were included. Using Stata V.17.0, a multilevel binary logistic regression analysis was performed to examine the factors…
Objective The aim of this study was to describe the literature that has been published on colorectal surgery patients’ experiences, including the challenges and solutions related to the transition from hospital to home. Background With surgery being an inevitable treatment for most individuals with colorectal disease, optimising the discharge transition from the hospital to home requires careful consideration of surgical patient experience, including a thorough understanding of their challenges during the transition period, particularly surrounding education. Design A search was conducted of…
Introduction Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic debilitating infection requiring prolonged multidrug therapy. Common symptoms contribute to inactivity, malnutrition and sarcopenia, and low muscle mass is associated with increased mortality. Evidence supporting exercise in NTM-PD is scarce, and no randomised controlled trial has evaluated its efficacy. This study aims to determine whether a 6-week hybrid, circuit-based exercise programme improves cardiorespiratory fitness compared with delayed intervention/usual care and to evaluate its effects on physical…
Introduction Digital tools such as virtual reality, mobile applications and digital devices are being implemented across various healthcare practice settings. Engagement in occupations is central to occupational therapy, supporting health and quality of life. Occupational therapists support people with disabilities to participate in occupations by enhancing their abilities or adapting tasks and environments. However, literature rarely specifies how digital technologies are used by occupational therapists, with whom they are implemented, when and where they are delivered, what occupations are…
Objective This study aimed to identify barriers and facilitators affecting implementation of perioperative music interventions in general practice. Design A qualitative implementation study using semistructured interviews. The updated Consolidated Framework for Implementation Research (CFIR) was used to guide data collection and analysis. The domains used were: innovation, outer setting, inner setting and individuals. Primary outcomes were barriers and facilitators for the implementation of perioperative music interventions in general practice. Setting General practices in the Netherlands…
Introduction Cerebral palsy (CP) is a neurodevelopmental disorder characterised by permanent motor impairments that substantially affect functional performance and quality of life. Whole-body vibration therapy (WBVT) has shown potential benefits for improving motor outcomes in children with CP; however, current evidence remains limited by small sample sizes and heterogeneous intervention protocols. This study aims to evaluate the effects of WBVT as an adjunct to conventional rehabilitation in children with CP. Methods and analysis A single-centre, two-arm randomised controlled trial will be…
Introduction Acute mountain sickness (AMS) commonly occurs during rapid ascent to high altitudes and significantly affects the health and cognitive function of travellers and specialised personnel in high-altitude environments. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive, safe and portable neuromodulation technique with potential benefits for AMS. This protocol evaluates taVNS efficacy for AMS and associated cognitive impairment and explores its mechanisms via multiomics analyses. Methods and analysis This is a single-centre, randomised, double-blind…
Introduction Psoriatic arthritis is a chronic inflammatory disease that can affect the axial skeleton as well as the joints and enthesis. Following the failure of conventional synthetic disease-modifying antirheumatic drugs (DMARDs), numerous biological DMARDs (b-DMARDs) or targeted synthetic DMARDs are now available, although current guidelines do not recommend a specific mode of action in the absence of comorbidities or contraindications. The aim of the study is to identify markers associated with the achievement of Minimal Disease Activity (MDA) at week 16 in patients treated with tumour…