The latest headlines across every section, pulled from official and open-access sources.
The Department of Health and Social Care’s (DHSC) annual statement on the actions it has taken to comply with the Concordat to Support Research Integrity.
Innovation drives progress. When it comes to innovation in the development of new drugs and therapeutic biological products, FDA’s Center for Drug Evaluation and Research (CDER) supports the pharmaceutical industry at every step of the process.
The product information has been updated for all domperidone products, to include a contraindication for patients with confirmed or suspected phaeochromocytoma (a rare tumour of the adrenal gland), due to the risk of episodes of severe hypertension.
For years, as Big Pharma poured billions into ADCs, Novartis CEO Vas Narasimhan notably stayed on the sidelines. Asked by Fierce during Novartis’ Q2 earnings call, Narasimhan explained why he is ending that holdout with the proposed $1.5 billion deal for Myricx.
In this interview, Matthew W. Martinez MD, FACC and Laurence S. Sperling, MD, FACC discuss “Prescribing Meals, Not Just Meds: The Case For Medically Tailored Mealsâ€.
Background The association between maternal iron status and the risk of gestational diabetes mellitus (GDM) remains elusive. Clearer evidence is needed to inform appropriate ferritin thresholds and iron supplementation guidelines during pregnancy. Objectives To investigate whether first-trimester serum ferritin (SF) concentration is associated with subsequent GDM risk. Design Retrospective cohort study. Setting A tertiary obstetrics and gynaecology hospital in Shanghai, China. Participants A total of 6429 low-risk pregnant women at fewer than 14 weeks of gestation were finally included…
Introduction Social isolation may have adverse effects on incidence and severity of cognitive impairment including subjective cognitive decline (SCD). An increase of environmental variety and social interactions may furthermore reduce progression from SCD to dementia. Research evaluating respective interventions is limited, particularly as regards studies comparing different degrees of social engagement interventions. We thus developed a clinical trial protocol to determine the efficacy of social interventions with different intensities in protecting cognitive function and white matter…
Objectives The focus of the present study is to highlight and understand the effect of hysterectomy on physical, psychological, social and marital status among women aged under 40 years of age, in the cultural context of Pakistan Design The study used a qualitative phenomenological approach to explore the lived experiences of the women. Settings The present study was conducted at Sheikh Zayed Hospital, a tertiary care public sector hospital located in Lahore, Pakistan. Participants The participants of the study were women under 40 years of age who have undergone hysterectomy in the last 2…
Objectives To identify the latent profiles of health behaviour abilities among patients with haematological malignancies and to explore the underlying population heterogeneity and influencing factors. Design A cross-sectional study conducted between October and December 2024. Setting Data were collected from three provincial hospitals in China. Participants A total of 486 hospitalised patients were recruited. Outcome measures Data were collected using a demographic questionnaire, the Sense of Coherence Scale-13, the Perceived Social Support Scale and the Self-rated Abilities for Health…
Introduction The study aims to demonstrate non-inferior clinical success (safety and efficacy) of the MOTUS Total Joint Replacement device relative to posterior or transforaminal lumbar interbody fusion with respect to a composite endpoint. The primary hypothesis for this study is that the probability of achieving 24-month composite clinical success (CCS) for subjects receiving the investigational device is not clinically inferior to the probability of achieving 24-month CCS for subjects receiving lumbar interbody fusion collected in a separate real-world evidence (RWE) study. Methods and…
Objective Respiratory syncytial virus (RSV) is an important viral pathogen in children, older adults and adults with certain high-risk conditions. In our prospective community-based cohort study of adults 50 years and older before the COVID-19 pandemic, the incidence of RSV acute respiratory infection (ARI) was 48.6 cases/1000 person-years (PY), which decreased to near zero during the COVID-19 pandemic. Our objective was to determine the incidence of RSV-ARI during the 2 years following the initial phase of the pandemic (2021–2022 and 2022–2023). Design This is a community-based prospective…
Objective This study was conducted to identify the individual and community level determinants of women’s autonomy of healthcare decision-making in extremely high and very high maternal mortality sub-Saharan African countries. Design The study utilised secondary data from the recent Demographic and Health Surveys conducted between 2014 and 2024. A multilevel mixed-effect logistic regression model was fitted. Adjusted OR (AOR) with a 95% CI was used to assess the strength and direction of association and statistical significance was considered at p value <0.05. Setting The study focused on…
Objectives To review how statistically non-significant indirect treatment comparison (ITC) results are interpreted within National Institute for Health and Care Excellence (NICE) cost-comparison evaluations (CCEs) and develop a framework to support interpretations of these results from Bayesian network meta-analyses (NMAs). Design A systematic review of CCEs between 2017 (first introduced) and April 2025. A framework (point-and-density plots) was developed to better interpret statistically non-significant NMA results for CCEs. Data sources CCEs were identified through NICE website searches…
Objectives This study aimed to explore how young and middle-aged adults (aged 18–65 years) with multimorbidity and complex chronic conditions experience hospitalisation and the transition home. Design In this qualitative study, semi-structured interviews were conducted. Data from the interviews were analysed using reflexive thematic analysis following Braun and Clarke (2022). Setting Two university hospitals in Switzerland (March to July 2024). Participants 16 young and middle-aged adults with multimorbidity and complex chronic conditions from two university hospitals in Switzerland were…
Introduction Chronic kidney disease (CKD) is a significant global health concern, contributing substantially to mortality; in advanced stages, adults often require kidney supportive care (KSC), a model of care/intervention that addresses complex palliative and supportive needs. These needs often remain insufficiently addressed, particularly among adults receiving haemodialysis, due to the interplay of multiple contextual factors and inconsistent reported outcomes. Consequently, it remains unclear how, for whom and under what circumstances KSC works (or does not work). Therefore, this rapid…
Introduction Successful pregnancies with healthy newborns have been reported after all types of solid organ transplantation (SOT). Limited data in young children suggest similar development and health compared with the general population. However, fetal development may be influenced by factors such as immunosuppressive medication and the increased incidence of pregnancy complications, and forthcoming health problems may only become apparent later in the life of the offspring. To allow for better investigation of the long-term health of offspring born after SOT, we designed the Transplantlines…
Introduction Musculoskeletal (MSK) conditions affect over 20 million people in the UK and account for one in seven General Practitioner (GP) consultations. To address capacity challenges, First Contact Physiotherapists (FCPs) now manage MSK patients in primary care. However, FCPs working in isolation from physiotherapy teams exhibit broad variation in decision-making that could pose risks to care quality. PRimary Care Individual Social Norms MSK Data Dashboard (PRISM) is a clinician-facing behaviour change digital dashboard that provides individualised social norms feedback such as, ‘you are…
Objectives This study examined temporal changes in burnout and working environments among Japanese resident physicians across the COVID-19 period and the preparation and implementation phases of the national workstyle reform. Furthermore, it assesses associated changes in their working environments. Design This study was conducted as a multicentre repeated cross-sectional study. Setting Data were used from the General Medicine In-Training Examination surveys conducted in 2020, 2022, 2023 and 2024. Participants Participants included postgraduate year 1 (PGY-1) and PGY-2 residents across Japan…
Introduction Cancer registries remain the gold standard for global cancer monitoring, yet complementing them with electronic health records and claims can significantly enhance the understanding of the cancer burden by providing a more complete picture of the patient journey. The main aim of this project is to serve as a proof of concept for using real-world data mapped to the Observational Medical Outcomes Partnership (OMOP) common data model (CDM) to monitor cancer epidemiology over time and characterise patients’ clinical history and outcomes. Methods and analysis This study will be…
Background INCA is a multicentre, prospective, randomised, two-arm superiority trial. 100 adult patients scheduled for primary total knee arthroplasty (TKA) will be randomised 1:1 to one of two locoregional analgesia strategies: group 1 (standard strategy), single-shot adductor canal block (ACB) combined with active surgeon-administered peri-articular infiltration with ropivacaine and participant-facing sham peripheral nerve blocks; group 2 (four-nerve block strategy), single-shot ACB combined with three additional ultrasound-guided nerve blocks (lateral femoral cutaneous, obturator and…
Introduction Cerebral hyperperfusion syndrome (CHS) is a severe complication following carotid endarterectomy (CEA). During emergence from general anaesthesia, residual anaesthetics induce mild respiratory depression and carbon dioxide accumulation, exacerbating hyperperfusion risks via hypercapnia-induced cerebral vasodilation. High-flow nasal cannula (HFNC) effectively reduces excessively elevated pressure of arterial carbon dioxide via multiple mechanisms including anatomical dead space washout. This trial aims to evaluate the effects of HFNC versus conventional mask oxygen therapy on…
Objective To examine the associations between registered nurses’ shift work patterns and sickness absence in hospital inpatient wards. Design Retrospective longitudinal study using 1.4 million e-roster and sickness absence records analysed with logistic mixed-effects models. Setting All adult acute inpatient hospital wards in two large healthcare organisations (Trusts) in England. Participants Registered nurses (N=7515) working across 95 adult acute wards in 2015–2020. Primary outcome measure Nurses’ sickness absence in relation to the shift pattern configurations worked in the previous 7…
Introduction Non-communicable diseases (NCDs), including cardiovascular diseases, diabetes, cancers and chronic respiratory diseases, account for a substantial proportion of global mortality and morbidity and represent a major challenge for the health system worldwide. Effective prevention and mitigation of NCDs requires coordinated strategies that combine health system interventions with population-level policies targeting key risk factors such as tobacco use, harmful alcohol consumption, unhealthy diets and physical inactivity. Evidence on actionable strategies implemented across diverse…
Introduction Hypoxic-ischaemic encephalopathy (HIE) is a leading cause of neonatal mortality and long-term neurodevelopmental impairment worldwide. Neonatal seizures are common in HIE and are associated with adverse outcomes. While antiseizure medications are routinely used for treatment, their prophylactic use in the absence of clinically evident seizures remains controversial, with limited consensus and variable clinical practices. Therefore, this review will map the existing evidence concerning the utilisation of antiseizure medication for prophylaxis among neonates with HIE. Methods and…