Background National paediatric intensive care registries are essential for benchmarking care, understanding population-level disease burden and identifying inter-site variation. However, such national-level data from the Middle East remains limited. This study aims to describe national patterns of paediatric intensive care unit (PICU) admissions, case mix, interventions, seasonality and outcomes across Kuwait. Methods This retrospective multicentre cohort study included all PICU admissions across the governmental hospitals in Kuwait between 1 January 2023, and 30 June 2025. Demographic…
Introduction Children with spastic cerebral palsy (CP) often exhibit significant changes in their skeletal muscles due to altered neural control and atypical mechanical loading. While muscle morphology, in particular muscle size, has been extensively studied, other important properties, such as passive stiffness and muscle composition, remain poorly characterised. Previous studies have typically examined these features in isolation, leaving the interactions among morphology, composition and passive stiffness largely unexplored. This protocol addresses these gaps by providing a comprehensive…
Introduction Medical residents frequently experience anxiety, depression, burnout and suicidal ideation. Existing support strategies have shown limited benefit. The Impact de la Pair-Aidance étudiante sur la Santé Mentale des internes de Médecine de première année (PAESSM) study will evaluate whether embedding Mental Health First Aid (MHFA)-trained peer supporters within a first-year residency cohort is associated with improved mental well-being and reduced psychological distress over 12 months. Methods and analysis PAESSM is a non-randomised controlled mixed-methods quasi-experimental study…
Introduction Anterior cruciate ligament reconstruction (ACLR) is complicated by high failure rates in young, active individuals, which is associated with worse outcomes and higher rates of osteoarthritis (OA). Failure of ACLR limits activity, reduces quality of life and substantially increases socio-economic costs. Thus, strategies to reduce ACLR failure are imperative. In the STABILITY 1 trial, we showed that adding a lateral extra-articular tenodesis (LET) to ACLR with a hamstring tendon (HT) graft provided greater stability than HT alone (Relative Risk Reduction (RRR)=0.38; 95% CI 0.21 to…
Introduction Existing evidence from cohort studies of atypical parkinsonism has demonstrated that median time from symptom onset to diagnosis is 3.4 years for progressive supranuclear palsy (PSP) and 3.1 years for multiple system atrophy (MSA). This compares to only 1.0–1.2 years in Parkinson’s disease (PD). Earlier diagnosis is essential to facilitate recruitment to disease-modifying treatment trials. In the Early Assessment, Diagnosis and Treatment of Parkinsonism and Related Syndromes study, we will prospectively assess patients across the UK with incident parkinsonism and determine the…
Rationale Cardiovascular disease is a major comorbidity in chronic obstructive pulmonary disease (COPD). Previous studies evaluating the association between inhaled corticosteroids (ICS) and cardiovascular events (CVEs) in COPD have yielded conflicting results and a potential dose–response relationship remains unclear. Objectives To determine the association between ICS exposure and risk of CVE in COPD patients. Methods In this nationwide, retrospective register-based cohort study, we included patients with a specialist-verified COPD diagnosis between January 2008 and January 2022. ICS…
Objectives This study aimed to investigate regional differences in needlestick injury (NSI) protection among clinical nurses across China’s economic regions and to explore the influencing factors including hospital management, training and assessment mechanisms. Study design A national cross-sectional survey was conducted using a stratified sampling strategy combined with online questionnaire dissemination. Mediation analysis was applied to examine the indirect effects of economic regions on NSI protection. Setting The survey was conducted across tertiary hospitals in 28 provincial-level…
Processa Pharmaceuticals has made a push into the autoimmune space via the acquisition of Vidya Therapeutics, which delivers a potential rival to Novartis’ Rhapsido.
The Medicines and Healthcare products Regulatory Agency has published guidance, developed in close partnership with NHS England, clarifying how existing medical device law applies to ambient voice technology (AVT) products used in health and care settings in Great Britain.
Device qualification and classification of ambient voice technology-enabled products that are medical devices intended to be placed on the market, or put into service, in Great Britain.
While acknowledging that changes must be made to the hospice industry, health policy researchers and providers worry that negative attention and the potential for overly punitive regulations could put patients at risk.
Congress appropriated $345 million for the Agency for Healthcare Research and Quality for the 2026 fiscal year, but the agency has spent less than $15 million on grants. AHRQ hasn’t issued a new one in over a year.
When surgery became unavoidable, a man with no insurance shopped around for the best price for a hernia repair — and saved thousands by traveling out of state.
Caldera Therapeutics has struck a reverse merger with the publicly traded Synlogic and inked a $278 million financing deal, continuing the meteoric rise of the inflammatory bowel disease startup.
AbCellera’s T-cell engager platform has reeled in a second client this summer, with Vertex paying $28 million upfront for a collaboration that will include autoimmune conditions.
529 Commerce, LLC of Parkland, Florida is recalling 3,860 units of its 4oz and 12 oz packages of its Rooted in Rare brand Aquafaba Powder because the product may contain undeclared egg. People who have an allergy or severe sensitivity to egg run the risk of serious or life-threatening allergic reac
July 29, 2026 ¬— Publix is recalling all lots of GreenWise Organic Whole Blueberries and Whole Mixed Berries because they may be contaminated with Escherichia coli O145:H28 (E. coli O145). E. coli O145 is a Shiga toxin-producing E. coli (STEC) that can cause illness characterized by severe stomach c
Objectives We aimed to estimate the time required to review and report cervical cytology slides within a Human Papillomavirus (HPV)-primary cervical cancer screening programme, where cytology is used for triage following a positive HPV test, comparing Artificial Intelligence (AI)-assisted digital cytology (Genius) with manual microscopy. Design A decision-tree model of the flow of slides through the National Health Service (NHS) England cervical screening cytology laboratory workflow, parameterised using published evidence and expert input. Setting Cytology laboratories within the NHS Cervical…
In the Original Investigation titled “Limbic System Microstructure in Neonates With Antenatal Opioid Exposure,” published July 2, 2026, the statement of the derivation of adjusted diffusion metrics in Methods should have listed all of these metrics. The article has been corrected.
This cohort study describes the implementation of human papillomavirus (HPV) self-collection testing during the annual wellness visit as well as HPV positivity rates and follow-up care among patients of an opioid treatment program.