Objectives To understand the association between population mental health and economic prosperity at the small area level in England and explore regional differences. Design A longitudinal small area-level analysis exploring the association between a proxy for population mental health and economic prosperity across 6789 small areas in England from 2011 to 2019 (N x T=61 101). We apply linear regression models with fixed effects at the area level. Mental health in each area is proxied by a standardised index constructed from administrative data on the use of services related to mental health…
Objectives To explore healthcare professionals’ perceptions and experiences with point-of-care testing (PoCT) implementation within Australia’s healthcare system and identify potential strategies for effective governance and improvements to regulation and guidelines that facilitate coordinated integration of quality PoCT into healthcare systems. Design A descriptive qualitative study with thematic analysis with codes derived inductively from the transcriptions and a structured framework analysis using the six building blocks of the WHO Health Systems Framework exploring barriers and enablers…
Objectives Pharmaceutical manufacturers routinely launch high-cost, specialty medicines, including biologics and biosimilars, with an accompanying patient support program (PSP). PSPs offer patients financial support, case management and clinical services to facilitate access to the promoted medicine. Because these programs are proprietary, there is little publicly available information, thus, this study aimed to generate in-depth understandings of the patient, health system and policy-level implications of relying on manufacturer PSPs for affordable access to high-cost medicines. Design…
Introduction Chronic musculoskeletal pain (CMP) is a leading cause of incurred personal healthcare costs and disability in the USA. It disproportionately affects rural populations, who are more likely to be uninsured, lack access to a regular healthcare provider and experience a higher prevalence of CMP. As a result of reduced access to non-pharmacological care, there is greater reliance on opioids. The Auricular Point Acupressure – Self-Management (APA-SM) program is a simple, needleless, evidence-based therapy that empowers individuals to self-manage their pain. Preliminary studies…
Introduction Interstitial lung diseases (ILDs) represent a heterogeneous group of disorders, which have in common persistent inflammation and/or pulmonary fibrosis, involving mainly but not exclusively the interstitium. This results in restrictive ventilatory physiology and limited respiratory reserve. Patients with ILD can have frequent exacerbations of their disease, with subsequent acute respiratory failure that may require admission to the intensive care unit (ICU). The diagnosis and management of ILD in the ICU presents unique challenges due to the paucity of evidence supporting survival…
Objectives Understanding the factors associated with the severity categories of fall-related injuries and intervening on modifiable determinants can mitigate the risk of serious fall injuries, thereby enhancing patient safety, reducing length of hospital stay and alleviating the economic burden imposed by these injuries. This study aims to identify factors associated with the severity categories of fall-related injuries and to explore differences in the clinical characteristics of patients who sustain such injuries. Design A retrospective observational study. Setting A tertiary care hospital…
Background: Cataract surgery is usually performed with topical anesthesia and sedation, which may be provided through a number of different care models with or without involvement of a physician anesthesiologist. We sought to describe anesthesiology care for cataract surgery in Ontario, Canada, and examine the association between the model of anesthesiology care and health service and perioperative outcomes after cataract surgery. Methods: We conducted a population-based study of patients who underwent cataract surgery in Ontario using linked health administrative data between 2012 and 2021…
Objective People with severe mental illness (SMI) engage in less physical activity (PA) and more sedentary behaviour (SB) than the general population, contributing to poorer physical health outcomes in this population. Therefore, the aim of this study was to evaluate the feasibility of a multi-component behaviour change intervention called Walking fOR Health (WORtH), delivered by community mental health teams, aimed at increasing PA and reducing SB compared with a one-off education session in people with SMI. Design Feasibility randomised controlled trial (RCT). Setting Study recruitment and…
This study assesses the integration of frontier large language models including tools such as optical character recognition (OCR) into the scientific peer review process to detect invisible text injection in an article under review.
This randomized clinical trial evaluates whether interaction with a large language model–based chatbot is more effective than existing public health resources for increasing parents' intent to vaccinate their child against human papillomavirus (HPV).
This economic evaluation analyzes the cost-effectiveness of initiating direct oral anticoagulant therapy for patients with device-detected atrial fibrillation to reduce the risk of stroke.
This cohort study evaluates medication restart patterns after hospital-initiated deprescribing, identifies factors associated with restart, and examines associations between restart and acute health care utilization.
This cohort study evaluates whether infertility treatment is associated with child neurodevelopment and whether such associations may be attributable to underlying subfecundity.
This survey study estimates acceptance among the Japanese public of emergency research without prospective consent for hypothetical scenarios involving hyperacute ischemic stroke.
This qualitative study examines the range of patient responses to automated text messages from their health care system and identifies considerations for improving health system communication design.
ACHIEVE Trials Demonstrate Comparative Benefits of Novel, Small-Molecule Oral GLP-1 RA, Expanding Oral Treatment Options for Patient Population in Need of Alternative Solutions mcarmody Sun, 06/07/2026 - 16:09 Press release ACHIEVE Trials Demonstrate Comparative Benefits of Novel, Small-Molecule Oral GLP-1 RA, Expanding Oral Treatment Options for Patient Population in Need of Alternative Solutions NEW ORLEANS, La. June 8, 2026 First Head-to-Head Trial Compares Two Oral GLP-1 RAs Effects on Glucose Control and Weight Changes in Type 2 Diabetes New data show the benefits of orforglipron…
Objectives To determine the prevalence, patterns and correlates of medicinal herb use in a rural Iranian population and to evaluate demographic and clinical predictors using adjusted regression models. Design Cross-sectional analysis of baseline data from the Fasa Prospective Epidemiological Research Studies in Iran Cohort Study. Setting Sheshdeh, a rural district in southern Iran. Participants 10 143 adults aged 35–70 years enrolled between 2017 and 2019. Primary outcome measures Prevalence of self-reported medicinal herb use during the past year and its associations with demographic…
Introduction In kidney transplantation, immunosuppressive therapy is essential to control alloimmune reactions, prevent graft rejection and improve patient survival rates. However, commonly used drugs like tacrolimus (TAC) and mycophenolate mofetil (MMF) have a narrow therapeutic window and exhibit significant inter- and intra-individual variability in pharmacokinetics (PK) and dose-response relationships. Recent pilot studies suggest that the gut microbiome may influence this variability. Methods and analysis ElucidatiNg Immunosuppressant pharmacokinetic variabilities by investigating Gut…