Introduction Effective perioperative pain management is a cornerstone of Enhanced Recovery After Surgery, yet standard opioid-based intravenous patient-controlled analgesia often leads to insufficient pain control, excessive adverse reactions and delayed recovery following laparoscopic abdominal surgery. Intrathecal morphine (ITM) has shown promising analgesic efficacy in abdominal and obstetric procedures but high-quality evidence supporting its use in major laparoscopic surgery remains limited. The ITM for postoperative analgesia in major laparoscopic abdominal surgery (IMPACT-Scope) trial…
Introduction Regular physical activity and limiting sedentary behaviour are important aspects in managing multiple sclerosis (MS). Fatigue is a common and disabling symptom in MS, contributing to impairments in activities of daily living and poorer quality of life. This study aims to determine the effectiveness of a physical activity and sedentary behaviour intervention, called iStep-MS, for reducing fatigue in people with MS when delivered across the MS care pathway. Methods and analysis This is a multicentre, two-arm randomised controlled superiority trial with embedded economic and process…
Introduction As the rates of child developmental delay and disability (referred onwards as developmental needs) increase globally, so does the number of caregivers caring for a child with developmental needs. It is well known that caring for a child with disability and/or delay leads to many challenges. While historically intervention services have focused on the child, it is increasingly being recognised that a whole family intervention approach is needed to improve both child and caregiver outcomes. The Now & Next programme is a family-centred, peer-led support programme targeted at…
Objective To explore the factors that affect communication about contraception and modern contraceptive use among first-time expectant mothers attending antenatal clinics in urban Accra, Ghana. Design A phenomenological qualitative study was conducted. In-depth interviews were conducted using a semistructured guide until data saturation was achieved. Interviews were audio-recorded and transcribed verbatim. Thematic analysis was performed, with data presented as narratives supported by quotes. Setting The study was conducted at one polyclinic in the city of Accra, Ghana. Participants…
by Jule Bachl, Melanie Hagen, Georg Schett Chimeric antigen receptor (CAR)-expressing cells bear a great potential for the treatment of autoimmune diseases. While numerous challenges persist, recent technological developments have demonstrated the potential for CAR cells to reset dysfunctional immune systems and transform care for patients with autoimmune disease. Chimeric antigen receptor (CAR)-expressing cells bear a great potential for the treatment of autoimmune diseases. In this Perspective, Jule Bachl, Melanie Hagen, and George Schett discuss the challenges and potential of recent…
by Wenjie Li, Wei Yang, Yang Liu, Ye Yao Background Understanding how respiratory infectious diseases spread across cities of different socioeconomic tiers is crucial for regionally targeted interventions. However, most spatial prediction frameworks neglect the combined influence of urban hierarchy and human mobility in shaping transmission risk. Methods and findings We integrated large-scale intercity mobility data into an agent-based branching process model to simulate the spatial diffusion of respiratory pathogens across mainland China. Three COVID-19 outbreaks were used for validation: the…
A phase 3 trial of Kolon TissueGene’s cell-based gene therapy has missed its co-primary endpoints. With a second late-stage study scheduled to report data in October, the biotech is holding off on determining the next steps for the osteoarthritis candidate.
This cohort study of patients with acute leukemia or myelodysplastic syndromes and/or myeloproliferative neoplasms compares clinical outcomes between matched related donor and mismatched unrelated donor transplant in the posttransplant cyclophosphamide era.
This randomized clinical trial assesses whether perioperative specialized immunonutrition reduces 30-day complications compared with standard oral isocaloric nutrition support among adults undergoing radical cystectomy for bladder cancer.
This randomized clinical trial examines the efficacy of a self-guided suite of mental health–focused applications with as-needed human support to reduce symptoms of anxiety and depression among women with breast cancer.
This randomized clinical trial assesses whether instruction delivery of the Patient Health Questionnaire-9 (PHQ-9) and the General Anxiety Disorder-7 (GAD-7) may influence symptom scores among US adults with anxiety or depression.
This cross-sectional study evaluates the association of state Supplemental Nutrition Assistance Program–related policies with county-level cardiovascular mortality rates.
This study from the INSPIRE-T Lifespan Translational Cohort evaluates whether accelerated epigenetic and inflammatory aging is associated with global intrinsic capacity, a multidomain measure of physical and mental health.
This cross-sectional study evaluates prevalence estimates, factors associated with, and treatment utilization among US military veterans with a history of suicidal thoughts and behaviors.
GSK said the mixed Phase 3 results for camlipixant mean this pill “is unlikely to transform patient care” in recurrent chronic cough. GSK is stopping work in this indication, a setback to a program once hoped to yield a new blockbuster product for the company’s respiratory drug portfolio. The post GSK Drug From $2B Deal Sputters in Phase 3 Test in Chronic Cough appeared first on MedCity News .
by Dongyu Liu, Yanyan Ni, Tiffany S. W. Ma, Xiaoyan Fan, Yongle Zhan, Ivan H. L. Lam, Matthew C. L. Lui, Tarani Chandola, Ichiro Kawachi, Pim Cuijpers, Michael Y. Ni Background Work-family conflict, defined as a type of inter-role conflict where demands from work and family roles are incompatible, is a global public health concern. Cross-sectional studies consistently demonstrate associations between work-family conflict and adverse mental health outcomes. However, longitudinal evidence remains mixed, highlighting the need for a comprehensive synthesis of available data to better understand…
by Ida Björk, Jenny Bolk, Gunilla Ajne, Ängla Mantel Background Vacuum-assisted delivery (VAD) is widely used in obstetric care, yet concerns remain regarding potential long-term neurodevelopmental sequelae in offspring, particularly after procedures performed at higher fetal head stations. Evidence on long-term outcomes after VAD remains limited. Given the safety concerns surrounding VAD, we investigated neonatal and long-term neurodevelopmental outcomes after VAD stratified by fetal head station, using emergency cesarean delivery (ECD) and spontaneous vaginal delivery as reference groups…
Introduction Reducing stunting remains a pressing global challenge, particularly in low and middle-income countries (LMICs), where nutrition insecurity and limited access to health services persist. With its large-scale national social assistance and health programmes, Indonesia offers valuable insights into implementing integrated strategies for stunting prevention. This study examines the substantive elements of food and social assistance interventions as well as the contextual and structural factors that influence their implementation. It also assesses how multisectoral collaboration…
Objective Sepsis management and antimicrobial resistance (AMR) are linked priorities. Early identification and treatment of sepsis with broad-spectrum antibiotics are key to reducing morbidity and mortality. We aimed to investigate clinicians’ decision-making about broad-spectrum antibiotics for suspected maternal sepsis in women admitted to hospital for childbirth, to identify if, how and why overtreatment may occur. Design Qualitative study. Semistructured interviews were conducted online, transcribed verbatim, coded in MAXQDA and analysed using the thematic Framework Approach. Setting…
Introduction The co-use of nicotine/tobacco products and cannabis among young adults is prevalent, yet little is known regarding the treatment impact of co-use and the underlying relationship between substances. No prospective treatment studies to date have evaluated the impact of cannabis use on nicotine cessation specifically among young adults, with an emphasis on dual-use substance patterns predicting outcomes. The overall goal of this protocol is to characterise the relationship between nicotine and cannabis and evaluate how patterns of co-use are associated with nicotine cessation…