In the Original Investigation titled “Cognitive Behavioral Therapy for Insomnia in Pain Management for Nonspecific Chronic Spinal Pain: A Randomized Clinical Trial,” published August 9, 2024, there were effect size errors in the Abstract and main article Results, Table 3, Table 4, and Supplement 2. The automation process of the effect size calculation caused the error. The effect sizes have been recalculated and updated. The authors have explained what happened in a Comment, and this article has been corrected.
This economic evaluation evaluates the frequency and cost associated with unindicated laboratory tests on paracentesis and thoracentesis specimens from patients with gynecologic cancers to highlight potential areas for improvement and waste minimization.
This cohort study evaluates the proportions, characteristics, and survival outcomes of patients in Korea diagnosed with lung cancer according to international screening eligibility criteria.
This cohort study compares the outcomes of adult patients undergoing systematic troponin screening with those undergoing clinical assessment alone during immune checkpoint inhibitor (ICI) therapy for cancer.
This cohort study compares clinicopathologic characteristics and progression-free and overall survival outcomes of patients with ERBB2-low vs ERBB2-null advanced gastric cancer.
This qualitative study of adults with type 1 diabetes examines their perspectives on how diabetes technology affects patients’ daily lives and psychosocial well-being.
This decision analytical modeling study estimates the trade-offs between mortality and treated retinopathy of prematurity associated with universal adoption of an oxygen saturation target in a simulated sample of infants based on US birth data.
Recurrent venous thromboembolism (VTE) is uncommon but associated with poor short-term survival among patients with cancer-associated thrombosis on extended apixaban therapy after at least six months of anticoagulation treatment, according to a post-hoc analysis of the API-CAT trial published July 13 in Circulation.
Introduction Physical inactivity is considered a major public health burden and remains highly prevalent across Gulf Cooperation Council (GCC) countries despite the rapid digital transformation and investment in health information infrastructure. Although technology-based interventions have emerged as promising approaches to promote physical activity, their implementation and impact are still unclear. This scoping review will map technology-based interventions that promote physical activity in the GCC against the domains of the Consolidated Framework for Implementation Research (CFIR) to…
Background Lumbar facet arthropathy (LFA) is a degenerative, arthritic joint disorder and a common specific cause of axial low back pain and functional impairment. Currently, no disease-modifying therapies are available for symptomatic LFA. Mesenchymal stem/stromal cell (MSC)-based therapy represents an emerging regenerative treatment modality with the promise to target the underlying pathophysiology of LFA. Despite encouraging clinical evidence supporting the safety and efficacy of MSC therapy in other osteoarthritis, its therapeutic utility in LFA remains largely unexplored. We recently…
Objective To identify the latent profiles of vicarious trauma among emergency trauma nurses in China and examine the factors associated with these profiles. Design A cross-sectional study. Setting 195 hospitals at Level 2 and above across 22 provincial-level administrative regions in China. Participants From January to March 2025, 930 emergency trauma nurses were recruited using a convenience sampling method (valid questionnaire response rate: 96.37%). All participants held a valid nursing practice certificate and had at least 1 year of trauma care experience. Primary and secondary outcome…
Introduction Healthcare professionals in general and academic hospitals increasingly face challenging behaviour from patients and their close contacts, particularly in acute care settings. Ranging from aggression to socially inappropriate actions, such behaviour is understood as interactional and context-dependent. Yet research largely focuses on verbal and physical aggression, leaving other forms and hospital context underexplored, despite concerns about staff safety, workforce sustainability and care quality. Methods and analysis This scoping review aims to map literature on challenging…
Introduction Stroke remains a leading cause of disability and mortality worldwide, with an urgent need for novel therapeutic strategies to improve recovery. Bupropion hydrochloride, a norepinephrine–dopamine reuptake inhibitor, may promote motor and cognitive recovery due to its unique mechanism of action. To evaluate the efficacy and safety of early adjunctive treatment with bupropion hydrochloride versus placebo on functional recovery in patients with acute ischaemic stroke. Methods and analysis BASE is an investigator-initiated, multicentre, randomised, double-blind, placebo-controlled…
Introduction Major depressive disorder (MDD) is the most common comorbidity among individuals with borderline personality disorder (BPD), affecting over 85% of patients and leading to high recurrence rates and resistance to treatment. Traditional pharmacological and psychotherapeutic interventions often show limited efficacy in this population, highlighting the need for innovative treatment strategies. Emerging evidence suggests that the dorsolateral prefrontal cortex (DLPFC) plays a crucial role in the pathophysiology of both MDD and BPD. In addition, non-invasive brain stimulation…
Introduction Older adults are increasingly recognised as valuable contributors in health and social care research, yet their involvement as active research partners remains inconsistent and under-theorised across contexts. The aim of this study is to investigate how older adults are involved as active research partners in health and social care research and to build consensus on strategies and enabling conditions that can support and strengthen such involvement. Methods and analysis This study uses a sequential exploratory mixed-methods design comprising three phases. In the preparatory phase…
Introduction Out-of-home care experienced young people have elevated mental health needs, yet their mental health help-seeking remains insufficiently understood. Understanding help-seeking is critical for identifying barriers and facilitators that shape whether, how and from whom care-experienced young people seek and access mental health support. Existing syntheses are limited in scope and have under-represented quantitative evidence, residential care, care leavers and equity-relevant subgroups. This review will synthesise international evidence on sources, barriers and facilitators of mental…
Objective To systematically summarise recent evidence on endoscopic biopsy for gastric ulcer. Design Systematic review of clinical studies. Data sources PubMed, Embase, Cochrane Library, Web of Science, CNKI and CiNii Research were searched for studies published from 2015 to May 2025. Eligibility criteria Original studies involving adults with endoscopically diagnosed gastric ulcers or ulcerative gastric lesions directly informing biopsy strategy were eligible if they evaluated biopsy timing, number, site or related diagnostic outcomes. Data extraction and synthesis Two reviewers independently…
Introduction Ventilator-induced diaphragmatic dysfunction is increasingly recognised as an important complication of prolonged mechanical ventilation (MV) and a major contributor to difficult weaning and extubation failure. Although bedside diaphragmatic ultrasound has emerged as a useful tool for assessing diaphragm function, conventional indices such as diaphragm excursion and thickening fraction may be influenced by ventilatory mechanics and patient effort. Speckle-tracking ultrasound (STU), a deformation-based technique adapted from echocardiography, allows assessment of diaphragmatic…
Introduction Learning health systems (LHS) aim to improve care through repeated cycles that link data, learning and action. These systems have a goal to uphold equity through purposefully including patients and other stakeholders in co-design and using real-world data to identify and respond to inequities. However, evidence shows that LHS do not automatically produce equitable outcomes, and a gap persists between stated equity goals and the practical mechanisms used to build equity into system design, measurement and decision-making. This scoping review examines how equity and related…
Introduction Patients with chronic obstructive pulmonary disease (COPD) often suffer episodes of exacerbation (ECOPD). Respiratory syncytial virus (RSV) is an increasingly recognised cause of illness in adults. Yet the prevalence of RSV during ECOPD and its association with clinically relevant outcomes remain insufficiently defined. The RECODE study sought to determine the prevalence of RSV infection in patients with ECOPD and to assess the association between RSV and hospitalisation, length of stay, acute cardiovascular events and/or death. Methods and analysis Prospective, multicentre…