New research and findings from open-access journals and the U.S. research agencies.
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce has learned.
by Qiu-Yi Pan, Ya-Xue Wang, Xue-Ying Tang, Zan Hou, Bai-Qiang Dong, Qi-Wen Li, Bao-Qing Chen, Shou-Min Bai, Chen-Fei Wu, Ming Chen Background The cost-effective treatment strategy for radiation-induced lung injury (RILI) remains unclear. Our recent phase II randomized clinical trial has proved pirfenidone to be safe and effective for grade 2 or 3 RILI. Here, we aim to assess the cost-effectiveness of pirfenidone plus glucocorticoids versus glucocorticoids alone for the treatment of grade 2 or 3 RILI. Methods and findings We constructed a Markov model based on the individual-level data from our…
Introduction Schizophrenia is a chronic psychiatric disorder, frequently associated with stigma, including within healthcare settings that significantly impairs quality of life and may exacerbate symptoms. Virtual reality (VR), as an immersive tool, may allow healthy individuals to experience the first-person perspective of a patient experiencing psychotic symptoms. VR exposure may facilitate perspective-taking, foster empathy and help reduce stigma. However, the findings remain incomplete, with considerable variation between protocols and no data on implicit stigma. Here, we present a study…
Objectives To investigate the behavioural and social determinants of type 2 diabetes mellitus (T2DM) self-care adherence in South Ethiopia using the integrated health belief model (HBM) and health-related quality-of-life (HRQoL) frameworks. Design A cross-sectional study. Setting Three public hospitals in South Ethiopia: Wolaita Sodo University Comprehensive Hospital, Humbo Primary Hospital and Boditi Primary Hospital. Participants 404 systematically sampled adults aged 18–60 years with a confirmed diagnosis of T2DM who had been attending follow-up clinics for at least 12 months. Exclusion…
Introduction Hepatic encephalopathy (HE) is a major complication following transjugular intrahepatic portosystemic shunt (TIPS) placement, significantly affecting patients’ quality of life and long-term prognosis. This study aims to compare the efficacy of underdilated TIPS versus standard TIPS in preventing variceal rebleeding in patients with cirrhosis and portal hypertension and to evaluate the incidence of post-procedural HE. Methods and analysis This multicentre randomised controlled trial will be conducted across five Grade A tertiary hospitals in China. A total of 648 patients with…
Objective To examine the association between healthcare professionals’ (HCPs) perceptions of their hospitals’ attitudes towards workplace violence (HATWPV) and the prevalence of workplace violence (WPV) in China. Design, settings and participants This nationwide cross-sectional survey was conducted among HCPs from September 2022 to January 2023. Participants were recruited using a multistage sampling strategy across three provinces (Zhejiang, Henan, Guizhou) representing eastern, central and western China. A total of 2976 valid questionnaires from 92 medical institutions were analysed. Primary…
Objectives To determine the rate of coding-based discrepancies between admission and discharge diagnoses in hospitalised paediatric patients in China, identify associated factors and investigate the impact on length of stay (LOS) and total hospitalisation expenses. Design Retrospective observational study. Setting 30 tertiary children’s hospitals across seven geographical regions of China, 2016–2021. Participants 7 575 622 hospitalisation records aged under 19 years. Primary and secondary outcome measures Primary outcome: proportion of hospitalisations with inconsistent admission and discharge…
Introduction Armed conflict and war increasingly strain healthcare systems worldwide, particularly in regions affected by protracted violence and instability. Physicians practising in war settings must deliver care under conditions of insecurity, resource scarcity and health system disruption, yet graduate medical education (GME) largely prepares trainees for stable, high-resource environments. Residents and fellows are often underprepared for the clinical, ethical and operational challenges of armed conflict. This scoping review aims to map and synthesise the existing literature on…
Objectives Neglect is the leading cause of acute child protection interventions across high-income countries. In England, reducing the number of children subject to these interventions is a policy priority. However, limited evidence on the health and social factors driving recent trends in neglect constrains effective prevention. We aimed to assess the associations of area-level adult mental health, child poverty and employment, with recorded neglect, and to compare these associations with those observed for other forms of maltreatment. Design Longitudinal ecological study using panel data…
Introduction Over the last two decades, increases in adolescent mental health difficulties have been recorded alongside a rapid expansion in social media use. In response to these trends, on 10 December 2025, the Australian government implemented Social Media Minimum Age legislation prohibiting Australians under the age of 16 years from having social media accounts. The introduction of this legislation allows for a unique quasi-experimental investigation of the impact of social media use on adolescent mental health and the mechanisms through which social media may impact young Australian…
Objective To explore the barriers and facilitators influencing the implementation of continuous positive airway pressure from the perspective of healthcare providers (HCPs) in primary hospitals of four regions in Ethiopia. Design A qualitative descriptive study employing thematic analysis of data collected through in-depth interviews from the perspective of HCPs. Setting The study was conducted in twelve selected primary hospitals in four regions of Ethiopia: Oromia, Amhara, Tigray and Sidama. Participants 28 HCPs who worked in neonatal intensive care units (NICUs) and delivery rooms…
Introduction Cancer is the most common cause of disease-related mortality in children, highlighting the urgent need for improved care in this population. It is estimated that >15% of children diagnosed with cancer harbour a germline pathogenic variant in a cancer predisposition gene which confers an increased risk to develop cancer. There are over 100 genes associated with cancer predisposition syndromes (CPSs) and greater availability and acceptability of genetic testing in the last decade has facilitated their recognition in childhood. However, individually, each of these CPSs is rare…
Introduction The International Classification of Functioning, Disability and Health (ICF) represents a major milestone in understanding functioning and disability and is widely used in clinical practice, management and health research. Despite its relevance, implementation of the ICF remains inconsistent across health services and care settings. Evidence on barriers and facilitators to implementation remains fragmented, limiting the development of effective, context-sensitive implementation strategies. This scoping review aims to map barriers and facilitators influencing ICF implementation in…
Introduction Accelerated population ageing has resulted in increasingly diverse and complex care needs among older people, posing a major challenge to healthcare systems worldwide. Nursing personnel represent a core workforce in the delivery of healthcare and nursing services for older people, and their geriatric nursing competence (GNC) is closely associated with the quality of care provided, care outcomes and older people’s quality of life. Therefore, accurate assessment of GNC is essential for nursing education, workforce development and quality improvement. Although several instruments…
Objectives To examine the prevalence and domain-specific patterns of intrinsic capacity impairment among community-dwelling older adults with chronic diseases from selected urban communities in Nanjing, China; to identify factors associated with any-domain intrinsic capacity impairment; and to explore theory-driven, hypothesis-generating associations among eHealth literacy, sleep disorder, social frailty and intrinsic capacity. Design Community-based cross-sectional study. Setting 13 selected urban communities in Nanjing, Jiangsu province, China, from January 2025 to December 2025…
Introduction Falls are a major global health issue among older adults, leading to substantial physical, psychological and economic burdens. Fall risk screening is essential for early identification of high-risk individuals and enables targeted preventive interventions. Primary care, as the first point of contact in healthcare, is well-positioned to implement screening due to its accessibility and broad population coverage. However, existing reviews have examined fall prevention in primary care broadly, while evidence on the factors influencing the implementation of routine fall risk screening…
Eli Lilly has axed another trial of a gene therapy acquired in its $1 billion Prevail Therapeutics buyout, further denting the drugmaker’s chances of delivering a return on its investment.
QuantHealth raised $45 million in Series B funding to expand its AI platform, which simulates clinical trials before they run and predicts patient outcomes for pharma companies. The startup is aiming to cut the industry’s 90% trial failure rate and speed up the timelines for effective drugs to reach the market. The post QuantHealth Snags $45M to Simulate Clinical Trials Before Patients Ever Enroll appeared first on MedCity News .
Psychiatry
Emergency Medicine
Infectious Diseases
Gastroenterology and Hepatology
Public Health
This cross-sectional study assesses the interdependence of rural background and training as factors associated with rural practice among US physicians.