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Trends in MRSA, MSSA, E. coli, Klebsiella spp. and P. aeruginosa bacteraemia and C. difficile infection by financial year.
Epidemiological analyses of mandatory surveillance data on healthcare associated infections (HCAI); MRSA, MSSA and Gram-negative bacteraemia (Escherichia coli (E. coli), Pseudomonas aeruginosa ( P. aeruginoa), Klebsiella species (Klebsiella spp.)), and Clostridioides difficile (C. difficile) infection.
Epidemiological analyses of mandatory surveillance data on healthcare associated infections (HCAI); MRSA, MSSA and Gram-negative bacteraemia (Escherichia coli (E. coli), Pseudomonas aeruginosa ( P. aeruginoa), Klebsiella species (Klebsiella spp.)), and Clostridioides difficile (C. difficile) infection.
Epidemiological analyses of mandatory surveillance data on healthcare associated infections (HCAI); MRSA, MSSA and Gram-negative bacteraemia (Escherichia coli (E. coli), Pseudomonas aeruginosa ( P. aeruginoa), Klebsiella species (Klebsiella spp.)), and Clostridioides difficile (C. difficile) infection.
Epidemiological analyses of mandatory surveillance data on healthcare associated infections (HCAI); MRSA, MSSA and Gram-negative bacteraemia (Escherichia coli (E. coli), Pseudomonas aeruginosa ( P. aeruginoa), Klebsiella species (Klebsiella spp.)), and Clostridioides difficile (C. difficile) infection.
Epidemiological analyses of mandatory surveillance data on healthcare associated infections (HCAI); MRSA, MSSA and Gram-negative bacteraemia (Escherichia coli (E. coli), Pseudomonas aeruginosa ( P. aeruginoa), Klebsiella species (Klebsiella spp.)), and Clostridioides difficile (C. difficile) infection.
Illumina has filled two key C-suite posts, naming Mike Sullivan as chief commercial officer and Julie Coletti as chief legal officer as the DNA sequencing giant works to keep its turnaround on track after years of regulatory, geopolitical and investor turbulence.
Original new drug approval. solution, intravenous. Sponsor: Amneal
Original biologic license approval. vial, single-dose. Sponsor: Sanofi-Aventis U.S. Llc
The Medicines and Healthcare products Regulatory Agency (MHRA) published a review of the safety of albumins manufactured from UK-sourced plasma with respect to variant Creutzfeldt-Jakob disease (vCJD) risk in August 2023. A further review of the safety of five additional plasma derived medicinal products (Fibrinogen, Prothrombin Complex Concentrates (PCCs), C1 Esterase Inhibitor, Factor X and Protein C) manufactured from UK-sourced plasma with respect to vCJD risk has now been completed, with the results published in July 2026.
Quarterly reports on acquired carbapenemase-producing Gram-negative organisms (CPOs) identified in human samples in England.
The MHRA is urging people to “summer-proof your health” as warmer weather, travel, and changing routines can affect how medicines and medical devices work, with simple steps to help prevent avoidable harm.
Bristol Laboratories Limited is recalling one batch (7124002) of Phenoxymethylpenicillin 250 mg/5 ml Oral Solution Sugar Free due to product labelling issues.
“We were not expecting to see clinical responses so early,” Vaneet Sandhu, M.D., rheumatologist and vice president of clinical development at Fate Therapeutics, told Fierce.
Introduction Depression and anxiety are significantly elevated among undergraduate university students worldwide. Despite this, treatment rates among this population remain low. To address this gap, there is a need for not only the provision of treatment options but also for relevant scalable prevention interventions. Such programmes have become more common in high-income countries but remain limited in low-income and middle-income countries (LMICs). This scoping review will identify and map key components, delivery and assessment methods and reported outcomes of indicated prevention…
Background and aim(s) Ambulance staff have the highest sickness absence, burnout and turnover intentions in the National Health Service, with work-related stress and anxiety identified as key drivers. Although multiple occupational stressors have been reported, it remains unclear which have the greatest impact. This study examined which work stressors are most strongly associated with mental health, well-being and intention to leave; whether these associations are explained by stress appraisals and mental rest; and which staff are most vulnerable to adverse outcomes. Methods A mixed-methods…
Introduction Most patients undergoing coronary artery bypass grafting (CABG) receive preoperative antiplatelet therapy to reduce ischaemic events but this increases perioperative bleeding and transfusion risk. Tranexamic acid, aminocaproic acid, aprotinin and desmopressin are commonly employed to reduce such risk; however, robust direct head-to-head comparative evidence remains limited in this specific population. Therefore, we will conduct a network meta-analysis (NMA) of randomised controlled trials (RCTs) to compare their relative efficacy and safety. Methods and analysis We will…
Objectives To determine whether insufficient balloon dilatation during endoscopic papillary balloon dilatation (EPBD) is associated with postendoscopic retrograde cholangiopancreatography pancreatitis (PEP) and prolonged hospitalisation and to identify clinical and anatomical factors related to insufficient dilatation. Design Multicentre retrospective cohort study with propensity score matching analysis. Setting Three tertiary referral hospitals in China: Union Hospital of Tongji Medical College of Huazhong University of Science and Technology, the Gastroenterology and Endoscopy Center of the…
Introduction Lung cancer surgery is a cornerstone of curative treatment for resectable disease, but postoperative recovery is often prolonged and may be complicated by impaired pulmonary function, reduced physical activity, symptom burden and delayed functional restoration. Wearable devices may support perioperative physical activity through objective monitoring and activity promotion; however, existing evidence remains fragmented and has not been synthesised in a focused review. This protocol describes a systematic review and meta-analysis to evaluate the association of wearable device-based…
Introduction Given the metabolic vulnerability of colorectal cancer (CRC) cells, periodic fasting-mimicking diets (FMDs) have emerged as a promising dietary strategy for improving clinical outcomes. Although preclinical studies have suggested that FMDs may suppress tumour growth and early-phase clinical trials have demonstrated their safety and feasibility, evidence regarding their effects on long-term survival outcomes in CRC remains limited because of certain constraints in patient cohorts and study designs. Method and analysis This multicentre, prospective, randomised controlled trial will…
Background Child undernutrition has remained a major public health problem. Preconception care is evident to improve pregnancy outcomes. However, the role of preconception care services in long-term child health outcomes is unknown. Objective To compare the nutritional status of preschool children born to women who received preconception care with children born to women who did not receive preconception care. Design This was an analytical cross-sectional study conducted 2 years after the end of the preconception care services provided. Settings Rural area in Nashik district, including two…
Introduction Most patients undergoing renal transplantation experience moderate to severe postoperative pain, which may induce physiological stress, exacerbate preexisting complications and impair functional recovery of the transplanted kidney. Although opioids are commonly used for postoperative analgesia, they are associated with various opioid-related adverse events (ORAEs). Oliceridine, a novel G protein-biased ligand μ-opioid receptor agonist, has been shown to provide effective analgesia while reducing the incidence of ORAEs without adversely affecting renal function. Therefore…
Introduction Wounds are one of the most common causes of emergency department visits. Their care often involves stitches, a potentially painful and stressful procedure. Pain and stress management is usually based on local anaesthesia, which is not always optimal. Medical hypnosis may offer a non-pharmacological alternative. Heart rate variability is a pain-free, easy-to-use and objective biomarker of stress. This study aims to assess the benefit of hypnosis on stress and pain during stitching using a randomised controlled trial. Methods and analysis This is a single-centre, randomised…
Background Cervical cancer remains a leading cause of morbidity and mortality among women in Ghana, yet screening coverage is extremely low and organised national programmes are limited. Although several studies have examined determinants of screening, no comprehensive synthesis has summarised the evidence to guide effective policy and intervention design. Objective To synthesise existing evidence on determinants of cervical screening in Ghana and identify opportunities to strengthen national screening strategies. Design This is a systematic review conducted following Aromataris and Pearson’s…