The latest headlines across every section, pulled from official and open-access sources.
Restless legs syndrome is a sleep-related neurologic disorder that causes an overwhelming urge to move the limbs, which can cause substantial sleep disturbance. Author John W. Winkelman, MD, PhD, of Harvard Medical School joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the symptoms, risk factors, diagnosis, and treatment of restless legs syndrome. Related Content: Restless Legs Syndrome
In this episode, we explore evolving evidence on anticoagulation after atrial fibrillation ablation, long-term outcomes with immunotherapy for melanoma, and promising new treatments for hepatitis D and triple-negative breast cancer. We review advances in physiologic pacing for heart failure and work through a challenging case involving fever, rash, and neurologic symptoms. An article considers fairness for late-career physicians, and Perspectives discuss misconceptions about autism, access to contraception, and the financial pressures shaping health care.
Dr. Centor discusses the comparative risk for severe gastrointestinal adverse events associated with dulaglutide, semaglutide, and tirzepatide with Dr. Wajd Alkabbani.
Efficacy supplement (new or revised indication). implant, implantation. Sponsor: Organon
Vonoprazan (3:30), newborn respiratory distress (6:40), immunization schedule recommendations (12:10), calcium supplementation during pregnancy (16:30), resistant hypertension (19:10), and DNA-based blood test for colorectal cancer (23:20).
This week, we explore new evidence on managing asymptomatic carotid stenosis, restoring vision in advanced macular degeneration, and preventing migraine in children. We discuss innovative cellular therapy for autoimmune disease, review sudden cardiac arrest in athletes, and describe a case of severe systemic infection with vision loss. Perspectives examine global tobacco risks, the future of telehealth payment, Medicare coverage of new technologies, and the things physicians carry.
Mifepristone used with misoprostol is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration (FDA). Author G. Caleb Alexander, MD, MS, from Johns Hopkins discusses this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS. Related Content: The US Food and Drug Administration's Regulation of Mifepristone Politics, Science, and the Future of FDA Drug Regulation
Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldwide. JAMA Review author Haeseong Park, MD, MPH, from the Dana Farber Cancer Institute, discusses this and more with JAMA Senior Editor Karen Lasser, MD, MPH. Related Content: Gastric Cancer
This week, we explore new options in cardiovascular prevention, fish-oil supplementation in dialysis patients, RSV vaccination, and cutting-edge cellular therapy for leukemia. We discuss advances in lung cancer treatment, approaches to functional dyspepsia, and a complex case of severe infection after travel. Perspectives examine access to and cost of weight-loss drugs, the promise and risks of AI in clinical care, and what it means to care for others while carrying personal loss.
Dr. Centor discusses dietary interventions for patients with irritable bowel syndrome with Dr. Imran Aziz.
This week, we share advances in treatment for EGFR-mutated lung cancer, a brain-penetrant enzyme therapy for a rare pediatric disorder, and dual targeting of extramedullary myeloma. We review cardiogenic shock, work through a challenging diagnostic puzzle in a young woman with recurrent illness, and explore Perspectives on corporatized care, vaccine policy, AI in medicine, and where clinicians carry grief.
Management of ankle sprains (1:20), axillary hyperhidrosis (5:10), dementia evaluation (7:40), frailty scoring (11:20), heart failure with preserved ejection fraction risk prediction (13:50), and AFP Clinical Answers (16:00).
JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA Clinical Reviews podcasts in 2025. Related Content: Managing Adverse Effects of Obesity Medications Diagnosis and Management of Hypothyroidism Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment Managing Adverse Effects of Incretin-Based Medications for Obesity Hypothyroidism Diagnosis and Treatment of Type 2 Diabetes in Adults JAMA Editors' Choice 2024: Clinical Reviews Podcasts
In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural Research of the Year roundup. Related Content: Research of the Year 2025
A case of rabies has been reported in a traveler from Morocco. Travelers potentially exposed to rabies in Morocco should immediately seek medical care. Upon returning home, travelers should follow up with their health care provider as soon as possible.
Illness and death due to Rocky Mountain spotted fever (RMSF) have been reported in the northern region of Mexico along the U.S. border, particularly in Baja California, Sonora, Chihuahua, Coahuila, and Nuevo León.
The 2025/26 influenza season has begun earlier than the previous two seasons, driven by the recently-emerged influenza virus A(H3N2) subclade K.
This is a third episode of our ECDC: On Air podcast sub-series - the "Risk Wire" - focusing on Risk Assessments ECDC publishes. This time we look into a prolonged multi-country outbreak of Salmonella Strathcona has affected 17 European countries and has been ongoing since 2023, with more than 400 confirmed cases reported so far. Investigations have identified small tomatoes as the most likely vehicle of infection, highlighting the complexity of foodborne outbreaks and the role of the environment in food contamination. In this episode, we talk to Dr Taina Niskanen, Expert in Food-, Waterborne…
Obesity affects more than 1 billion people worldwide and is recognized by the World Health Organization as a chronic, relapsing disease. WHO recently published a guideline in JAMA on the use and indications of GLP-1 therapies for the treatment of #obesity in adults. Francesca Celletti, MD, PhD, and Ezekiel Emanuel, MD, PhD, join JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss. Related Content: World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults
This week, we look at ctDNA-guided immunotherapy for bladder cancer, cardiovascular outcomes with tirzepatide, and evidence that one HPV vaccine dose may be enough. We explore high-dose rifampin for tuberculous meningitis, review measles amid rising outbreaks, and follow a challenging case of gastrointestinal bleeding. Essays examine how clinicians navigate post-Dobbs care, tobacco harm among people with mental illness, congenital syphilis, and sustaining medical research.
Efficacy supplement (new or revised indication). injectable, intravenous. Sponsor: Incyte Corp
Original biologic license approval. injection. Sponsor: Glaxosmithkline Llc
Dr. Centor discusses complications of cardiac implantable electronic devices with Dr. Peter Zimetbaum.