This week, we present new research on treatment for muscle-invasive bladder cancer, left atrial appendage closure versus medical therapy for atrial fibrillation, gene-editing approaches for sickle cell disease and β-thalassemia, and the safety of discontinuing beta-blockers after myocardial infarction. We also review GLP-1 receptor agonists and discuss a Clinical Problem-Solving case of a man with progressive confusion. Perspectives explore corporatization; biologic, as opposed to chronologic, aging; and a legal case that could affect mental-health policy.
Absolute iron deficiency with or without anemia affects about 2 billion people worldwide and 14% of adults in the US. Discover causes, diagnosis, and best practices for oral and intravenous iron therapy in adults in this discussion between Michael Auerbach, MD, from Georgetown University School of Medicine, and JAMA Associate Editor Margaret Wheeler, MD. Related Content: Iron Deficiency in Adults
Every month ECDC provides detailed epidemiological overview of the worldwide transmission of chikungunya virus disease in its weekly threat report (Communicable Diseases Threat Report).
Every month ECDC provides detailed epidemiological overview of the worldwide transmission of dengue in its weekly threat report (Communicable Diseases Threat Report).
Interview with Thomas Ibounig, MD, author of Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging and Brian T. Feeley, MD, author of Magnetic Resonance Imaging Abnormalities and Incidental Age-Related Changes. Hosted by Eve Rittenberg, MD. Related Content: Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging Magnetic Resonance Imaging Abnormalities and Incidental Age-Related Changes
This week, we present new clinical trials on immunotherapy for stage III mismatch repair–deficient colon cancer, early surgery for asymptomatic aortic stenosis, an approach to dengue virus suppression, and advances in gene and prime-editing therapies for rare disorders. We also review minipuberty. We follow the case of a 12-year-old girl with altered mental status and persistent hypoglycemia, and we explore Perspectives on corporate influences on health, vaccine communication, antitrust policy, conflicts of interest, and the meaning of the number needed to treat.
There is an outbreak of meningococcal disease in the Mangembo Health Zone of Kongo Central Province. The best way to protect yourself is to get meningococcal vaccination.
Resistant hypertension affects about 10% of those treated for hypertension. Managing it involves lowering sodium intake, exercising, losing weight, reducing alcohol consumption, and using optimal diuretics, combination pills, and mineralocorticoid antagonists. Author Michel Azizi, MD, PhD, from Hospital European Georges Pompidou in France discusses this and more with JAMA Associate Editor David L. Simel, MD, MHS. Related Content: Diagnosis and Management of Resistant Hypertension
Tuberculosis remains a significant public health challenge in Europe, despite often being considered a disease of the past. In this episode of ECDC: On Air , tuberculosis expert Senia Rosales-Klintz explains the current reality of TB, how the bacteria can remain dormant for years, and how it primarily affects vulnerable populations. The episode also explores social stigma, challenges in accessing newer treatments, and the critical role of tracking patient outcomes in eliminating the disease. Click here for more information on World Tuberculosis Day, and here for more information in general…
Peanut allergy affects about 2% of people in the US and most commonly develops in early childhood. Peanut introduction during infancy has led to decreased prevalence of peanut allergy. Author Elissa Abrams, MD, MPH, of the University of Manitoba joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the clinical presentation and methods to diagnose, treat, and decrease the risk of peanut allergy. Related Content: Peanut Allergy
As of March 2026, over 1 000 confirmed and possible cases of shigellosis and other gastrointestinal infections, including salmonellosis, have been detected in travellers returning from Cabo Verde to several countries in the European Union/European Economic Area (EU/EEA), the United Kingdom (UK), and the United States (US), with new cases still being reported.