Introduction Healthcare professionals in general and academic hospitals increasingly face challenging behaviour from patients and their close contacts, particularly in acute care settings. Ranging from aggression to socially inappropriate actions, such behaviour is understood as interactional and context-dependent. Yet research largely focuses on verbal and physical aggression, leaving other forms and hospital context underexplored, despite concerns about staff safety, workforce sustainability and care quality. Methods and analysis This scoping review aims to map literature on challenging…
Introduction Stroke remains a leading cause of disability and mortality worldwide, with an urgent need for novel therapeutic strategies to improve recovery. Bupropion hydrochloride, a norepinephrine–dopamine reuptake inhibitor, may promote motor and cognitive recovery due to its unique mechanism of action. To evaluate the efficacy and safety of early adjunctive treatment with bupropion hydrochloride versus placebo on functional recovery in patients with acute ischaemic stroke. Methods and analysis BASE is an investigator-initiated, multicentre, randomised, double-blind, placebo-controlled…
Introduction Major depressive disorder (MDD) is the most common comorbidity among individuals with borderline personality disorder (BPD), affecting over 85% of patients and leading to high recurrence rates and resistance to treatment. Traditional pharmacological and psychotherapeutic interventions often show limited efficacy in this population, highlighting the need for innovative treatment strategies. Emerging evidence suggests that the dorsolateral prefrontal cortex (DLPFC) plays a crucial role in the pathophysiology of both MDD and BPD. In addition, non-invasive brain stimulation…
Introduction Older adults are increasingly recognised as valuable contributors in health and social care research, yet their involvement as active research partners remains inconsistent and under-theorised across contexts. The aim of this study is to investigate how older adults are involved as active research partners in health and social care research and to build consensus on strategies and enabling conditions that can support and strengthen such involvement. Methods and analysis This study uses a sequential exploratory mixed-methods design comprising three phases. In the preparatory phase…
Introduction Out-of-home care experienced young people have elevated mental health needs, yet their mental health help-seeking remains insufficiently understood. Understanding help-seeking is critical for identifying barriers and facilitators that shape whether, how and from whom care-experienced young people seek and access mental health support. Existing syntheses are limited in scope and have under-represented quantitative evidence, residential care, care leavers and equity-relevant subgroups. This review will synthesise international evidence on sources, barriers and facilitators of mental…
Objective To systematically summarise recent evidence on endoscopic biopsy for gastric ulcer. Design Systematic review of clinical studies. Data sources PubMed, Embase, Cochrane Library, Web of Science, CNKI and CiNii Research were searched for studies published from 2015 to May 2025. Eligibility criteria Original studies involving adults with endoscopically diagnosed gastric ulcers or ulcerative gastric lesions directly informing biopsy strategy were eligible if they evaluated biopsy timing, number, site or related diagnostic outcomes. Data extraction and synthesis Two reviewers independently…
Introduction Ventilator-induced diaphragmatic dysfunction is increasingly recognised as an important complication of prolonged mechanical ventilation (MV) and a major contributor to difficult weaning and extubation failure. Although bedside diaphragmatic ultrasound has emerged as a useful tool for assessing diaphragm function, conventional indices such as diaphragm excursion and thickening fraction may be influenced by ventilatory mechanics and patient effort. Speckle-tracking ultrasound (STU), a deformation-based technique adapted from echocardiography, allows assessment of diaphragmatic…
Introduction Learning health systems (LHS) aim to improve care through repeated cycles that link data, learning and action. These systems have a goal to uphold equity through purposefully including patients and other stakeholders in co-design and using real-world data to identify and respond to inequities. However, evidence shows that LHS do not automatically produce equitable outcomes, and a gap persists between stated equity goals and the practical mechanisms used to build equity into system design, measurement and decision-making. This scoping review examines how equity and related…
Introduction Patients with chronic obstructive pulmonary disease (COPD) often suffer episodes of exacerbation (ECOPD). Respiratory syncytial virus (RSV) is an increasingly recognised cause of illness in adults. Yet the prevalence of RSV during ECOPD and its association with clinically relevant outcomes remain insufficiently defined. The RECODE study sought to determine the prevalence of RSV infection in patients with ECOPD and to assess the association between RSV and hospitalisation, length of stay, acute cardiovascular events and/or death. Methods and analysis Prospective, multicentre…
Introduction Effective perioperative pain management is a cornerstone of Enhanced Recovery After Surgery, yet standard opioid-based intravenous patient-controlled analgesia often leads to insufficient pain control, excessive adverse reactions and delayed recovery following laparoscopic abdominal surgery. Intrathecal morphine (ITM) has shown promising analgesic efficacy in abdominal and obstetric procedures but high-quality evidence supporting its use in major laparoscopic surgery remains limited. The ITM for postoperative analgesia in major laparoscopic abdominal surgery (IMPACT-Scope) trial…
Introduction Regular physical activity and limiting sedentary behaviour are important aspects in managing multiple sclerosis (MS). Fatigue is a common and disabling symptom in MS, contributing to impairments in activities of daily living and poorer quality of life. This study aims to determine the effectiveness of a physical activity and sedentary behaviour intervention, called iStep-MS, for reducing fatigue in people with MS when delivered across the MS care pathway. Methods and analysis This is a multicentre, two-arm randomised controlled superiority trial with embedded economic and process…
Introduction As the rates of child developmental delay and disability (referred onwards as developmental needs) increase globally, so does the number of caregivers caring for a child with developmental needs. It is well known that caring for a child with disability and/or delay leads to many challenges. While historically intervention services have focused on the child, it is increasingly being recognised that a whole family intervention approach is needed to improve both child and caregiver outcomes. The Now & Next programme is a family-centred, peer-led support programme targeted at…
Objective To explore the factors that affect communication about contraception and modern contraceptive use among first-time expectant mothers attending antenatal clinics in urban Accra, Ghana. Design A phenomenological qualitative study was conducted. In-depth interviews were conducted using a semistructured guide until data saturation was achieved. Interviews were audio-recorded and transcribed verbatim. Thematic analysis was performed, with data presented as narratives supported by quotes. Setting The study was conducted at one polyclinic in the city of Accra, Ghana. Participants…
by Jule Bachl, Melanie Hagen, Georg Schett Chimeric antigen receptor (CAR)-expressing cells bear a great potential for the treatment of autoimmune diseases. While numerous challenges persist, recent technological developments have demonstrated the potential for CAR cells to reset dysfunctional immune systems and transform care for patients with autoimmune disease. Chimeric antigen receptor (CAR)-expressing cells bear a great potential for the treatment of autoimmune diseases. In this Perspective, Jule Bachl, Melanie Hagen, and George Schett discuss the challenges and potential of recent…
by Wenjie Li, Wei Yang, Yang Liu, Ye Yao Background Understanding how respiratory infectious diseases spread across cities of different socioeconomic tiers is crucial for regionally targeted interventions. However, most spatial prediction frameworks neglect the combined influence of urban hierarchy and human mobility in shaping transmission risk. Methods and findings We integrated large-scale intercity mobility data into an agent-based branching process model to simulate the spatial diffusion of respiratory pathogens across mainland China. Three COVID-19 outbreaks were used for validation: the…
These three legal regimes are pulling in different directions, and the developers that navigate them well will be the ones that plan for all three from the start. The post The AI Tension in Healthcare: Patent Strategy, FDA Reality, and HIPAA Constraints appeared first on MedCity News .
Rural Health Transformation Program funding gives states broad flexibility and may help address longstanding access gaps. The post For Millions in Rural America, Medicine Is Still Far Away appeared first on MedCity News .
Guidance for Sponsors, Industry, Researchers, Investigators, and Food and Drug Administration Staff - Form FDA 3674 - Certifications To Accompany Drug, Biological Product, and Device Applications/Submissions
This episode of CardiaCast will feature a discussion on the treatment of atherosclerotic cardiovascular disease (ASCVD) risk – from lifestyle to advanced therapies, led by Dr. Maya Safarova.
Macarthys Laboratories Ltd T/A Martindale Pharma has notified the MHRA of a manufacturing issue impacting several batches of Xaggitin XL Prolonged-release Tablets, due to the occurrence of incorrect tablet counts in the bottles.
A team of veteran scientists from elite institutions has come together to form a new center dedicated to the crafting of personalized genetic medicines, adding to the growing list of similar efforts in the wake of Baby KJ’s groundbreaking custom CRISPR treatment.
The supply of the circuit boards needed to fix the devices is significantly constrained, preventing the company from immediately correcting all affected ventilators.