Objectives To compare the reliability of four commonly used structured tools for risk-of-bias assessment in prognostic cohort studies and evaluate their agreement with expert appraisal. Design Methodological comparison study. Setting Secondary analysis of published prognostic cohort studies in patients with acute pulmonary embolism from a previously conducted systematic review. Participants Sixty-three cohort studies assessing the prognostic role of echocardiography in patients with acute pulmonary embolism. Primary and secondary outcome measures Four independent reviewers assessed study…
Introduction Primary liver cancers, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, are one of the leading causes of cancer-related mortality. Transarterial chemoembolisation (TACE) and radioembolisation (TARE) are established palliative treatments yet they are traditionally performed during inpatient hospitalisation. Recent technical and organisational advances allow for safe same-day ambulatory procedures. In particular, the extent to which ambulatory intra-arterial therapy aligns with patients’ expectations, comfort and quality of life remains poorly documented. The…
Objectives A growing body of evidence supports prehabilitation in cancer patients, but the findings have been inconsistent. This overview aimed to identify, evaluate and summarise the effect of prehabilitation on the clinical outcomes of cancer patients. Design Overview of systematic reviews. Data sources PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library and the JBI Evidence Synthesis database (Joanna Briggs Institute, University of Adelaide, Australia; hosted on Ovid) were searched from inception to January 2025. The search was updated in May 2026, and…
Objective This study was conducted to evaluate the effect of waste separation and recycling education on waste management awareness among nursing students at a university and to examine the psychometric properties of a measurement tool designed to assess this awareness. Method The research was conducted using a single-group pretest–post-test quasi-experimental and methodological design. The population of the study consisted of individuals receiving nursing education; 180 participants were included in the pretest and 117 in the post-test. Data were collected using a Demographic Information Form…
Objectives Internalised weight stigma (IWS) has been associated with lower physical activity (PA) levels in Western populations with diabetes, but evidence from Asian primary care settings remains limited. This study examined factors associated with PA levels, including IWS, among obese type 2 diabetic patients in Hong Kong primary care. Design Cross-sectional questionnaire study. Setting A single general outpatient clinic in Hong Kong. Participants 310 Chinese adults aged 18–69 years with type 2 diabetes and Body Mass Index ≥25 kg/m² who attended routine follow-up appointments were…
Introduction Hand expression is a manual method of milk expression that requires no equipment and is commonly used in the early postpartum period, particularly when direct breastfeeding is not possible or not effective. Randomised trials have reported mixed findings across different maternal–infant contexts. This review aims to synthesise randomised evidence on the effects of postpartum hand expression on expressed milk volume and breastfeeding outcomes. Methods and analysis We will include individually randomised parallel-group controlled trials involving human postpartum women expressing…
Introduction Emergency departments (EDs) operate under conditions of high demand, uncertainty and resource constraints, making efficient personnel rostering a critical component of healthcare delivery. Poorly designed staff schedules may contribute to increased waiting times, staff burnout, reduced quality of care and inefficient use of resources. Operations research (OR) methods, including mathematical programming, heuristics, metaheuristics and simulation-based optimisation, have been widely applied to workforce scheduling problems in healthcare. However, the specific application of these…
Functional precision medicine tests drugs directly on living tumor cells to help clinicians identify the most effective, personalized treatments for their patients. NCI Director Dr. Anthony Letai shares his personal journey with the technology and highlights next steps for advancing the field from a recent NCI workshop.
Following a string of clinical setbacks, Vistagen’s nasal spray for social anxiety has now failed to top placebo even when given as a double dose. But just like with prior disappointing readouts, the biotech has set its sights on a subpopulation it says may provide a path to FDA approval.
Tarsus Pharmaceuticals is fronting $450 million to acquire Alkeus Pharmaceuticals for its phase 3-stage retinal disease therapy that's being touted as a potential blockbuster.
PacBio has promoted an internal veteran to CEO after Christian Henry stepped down, tasking the new leader with improving sales, expanding the DNA sequencing company’s clinical reach and cutting costs.
BioVie has hailed phase 2 data as evidence that bezisterim could represent a “meaningful advance” in the treatment of Parkinson’s disease. But the biotech focused on a new composite measure, rather than its stated primary endpoint, and emphasized outcomes in a subpopulation of patients.
Conservatives who have long pushed for Medicaid work requirements often said vulnerable people would get a pass. But the federal government’s list of exemptions left off homeless people.
Sen. Andy Kim of New Jersey wants to offer universal healthcare until age 26. He sat down with KFF Health News’ Julie Rovner to answer the question: “How Would You Fix It?”
Context Therapeutics has stopped development of the bispecific T-cell engager CT-95, freeing up cash to extend its runway beyond readouts on its two priority clinical programs.
Actimed Therapeutics has brought the full rights to its wasting disease drug back in-house, securing “strategic control” over the asset but losing out on a shot at over $120 million in biobucks.
On July 13, 2026, Medline Industries, LP initiated a nationwide recall of Hudson RCI Neonatal/Infant Heated Wire Breathing Circuits. Medline received reports of sporadic failures involving the electrical connector of certain neonatal and infant heated wire breathing circuits. In affected circuits, t