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Cadence raised $100 million in Series C funding to scale its AI-powered chronic care platform, which monitors patients at home and adjusts their medications in real time. The startup, now valued at $1.23 billion, partners with health systems to treat patients with heart failure, hypertension and diabetes. The post Cadence Rakes In $100M to Automate Chronic Care at Scale appeared first on MedCity News .
J. Chuquimia Valdez et al.
Y. Zeng et al.
E. Hernández-Sánchez et al.
C. D. Gowler et al.
J. Wight et al.
Introduction Mental health is now recognised as a major global concern affecting people from diverse backgrounds. There is growing evidence that the gut microbiota plays a crucial role by producing metabolites that significantly influence a person’s mood and behaviour. Despite its importance, there is a significant gap in the profiling and understanding of the gut microbiota’s influence on mental health among Malaysians. Therefore, this study aims to determine gut microbiome profiles among patients with major depressive disorders (MDD) of different treatment groups attending psychiatric…
Objectives This study investigated the impact of heat on the risk of hospital admission due to a range of health conditions in England. Design We used records of over 4 million hospital admissions in the summer months between 2008 and 2019, to construct daily time series of admissions in 32 837 census areas. Coupled with high-resolution environmental data, we conducted a case time-series analysis using distributed-lag non-linear models to measure the lagged relationship between summertime temperature and risk of admission for a broad set of health conditions. We derived the relative risks of…
Background The WHO defines self-care as ‘the ability of individuals, families and communities to promote health, prevent disease, maintain health and cope with illness and disability with or without the support of a healthcare provider’, while self-care confidence refers to an individual’s perceived ability to effectively engage in these activities. The interface between health and care professionals (HCPs) and the public is pivotal in promoting self-care behaviours, yet barriers such as health literacy deficits, professional constraints, misconceptions and disparities in self-care confidence…
Objectives This qualitative systematic review aimed to describe the experiences and perspectives of loneliness and social isolation among informal caregivers of people with chronic kidney disease (CKD). Methods Terms for caregivers, qualitative research, loneliness and social isolation and CKD were entered into MEDLINE, Embase, CINAHL and PsycINFO and searched from inception to May 2025. Qualitative studies that described social isolation and loneliness among caregivers of people with CKD were included in this review. Study characteristics were extracted into Microsoft Excel. Qualitative data…
Objectives Enteral nutrition (EN) constitutes a critical therapeutic intervention in the management of patients with sepsis; however, the optimal timing for its initiation remains uncertain. This study sought to evaluate the impact of early versus delayed EN on mortality rates and clinical outcomes among adult patients with sepsis in intensive care units (ICU). Design Retrospective cohort study using propensity score matching (PSM) methodology. Setting A tertiary hospital ICU in Hebei Province, China, from 2015 to 2024. Participants This retrospective analysis involved adult ICU patients with…
Introduction Falls are a major global public health challenge and a leading cause of severe consequences, such as fractures, traumatic brain injuries and even death among older adults. Older adults with knee osteoarthritis (KOA) are at a higher risk of falling and tend to experience more severe injuries due to impaired balance. Baduanjin, a mind-body exercise, has been shown to improve lower limb muscle strength and balance in older adults and to reduce fall risk in those with KOA; however, its specific mechanisms remain unclear. Therefore, this study aims to examine the effectiveness of…
Objectives Rising demand for emergency care in England is a continuing challenge driven by population ageing and increasing multimorbidity. Ambulatory emergency care (AEC) refers to the provision of same-day acute care for patients who might otherwise require admission. However, the contribution of AEC conditions to demand remains unclear. This study aimed to examine the proportion and nature of patients attending emergency departments (ED) with AEC-related conditions and to describe variation between hospitals in attendances and emergency admissions for AEC conditions. Design and setting A…
Introduction Common mental disorders (CMDs) are endemic globally. The availability of evidence-based mental health interventions has grown rapidly, with many services focused on psychotherapy. Most psychotherapies require multiple sessions, resulting in lengthy waiting times due to limited provider availability. These delays can lead to higher morbidity, poorer adherence and less favourable outcomes. Recent research indicates that single-session therapy (SST) can be as effective as multi-session approaches and offers cost savings. This pragmatic, prospective mixed-methods pilot cohort study…
Introduction Integrated care represents a transformative approach to delivering person-centred healthcare, aiming to reduce health inequalities, improve outcomes and boost system efficiency. The WHO advocates integrated care, which is also a central pillar of the UK government’s National Health Service (NHS) 10-year plan. However, there remains a significant evidence gap regarding optimal organisational strategies for designing and delivering integrated care services. Multiple long-term conditions (MLTCs) refer to the coexistence of two or more chronic physical and/or mental health conditions…
Introduction While evidence consistently demonstrates elevated COVID-19 risks among people with intellectual and physical disabilities, less is known about how household living arrangements shape these inequalities. Residential setting and household size influence exposure, capacity to isolate and reliance on care yet have rarely been examined jointly with disability status at a population scale. This study aims to estimate disability-related inequalities in COVID-19 infection, hospitalisation and mortality in Scotland and to assess whether residential setting and household size modify these…
Introduction Family members of survivors of critical illness are known to experience adverse outcomes in the months following the critical care admission, which can impact their physical, social and emotional health. This protocol describes the Family or Caregiver Outcomes after critical illness (FOCUS) study, which aims to develop a core outcome set (COS) for trials involving family members of critical care patients across the continuum of care. Methods and analysis A modified Delphi consensus process with researcher, clinician and patient/caregiver stakeholder groups and consensus meetings…
Introduction Peripheral neuropathic pain (PNP) is common, disabling and frequently refractory to pharmacotherapy. High-frequency repetitive transcranial magnetic stimulation (rTMS) can reduce neuropathic pain but response rates remain variable. Personalised target selection based on functional connectivity may improve analgesic efficacy and help elucidate neurobiological mechanisms. Methods and analysis This is a prospective, multicentre, randomised, double-blind, controlled superiority trial recruiting 152 adults with PNP (eg, trigeminal neuralgia, postherpetic neuralgia and diabetic…
Introduction Postoperative neuropsychological disorders including delirium, cognitive dysfunction and emotional distress are common after cardiac surgery and are linked to reduced quality of life, morbidity and mortality. Reliable preoperative risk factors remain difficult to identify. This study investigates stress-related parameters as predictors of postoperative neuropsychological disorders in patients undergoing cardiac surgery. Methods and analysis In this prospective study, 240 patients undergoing elective cardiac surgery (coronary artery bypass grafting: n=120, aortic valve replacement…
Introduction Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with reduced quality of life and increased healthcare utilisation. AF is increasingly recognised as a manifestation of an underlying cardiometabolic disease process, with obesity and related metabolic risk factors contributing to its development and progression. Consequently, upstream risk factor modification, including structured weight management, has emerged as a potential strategy to improve AF outcomes. While dietary and exercise interventions have been studied individually, the…
Introduction Depression is a major global health challenge, with onset commonly occurring in youth. There is an urgent need to better understand the epidemiology of depression to facilitate better interventions and preventions that are person-specific and time-specific. Long-term depression trajectories and ecological momentary assessment (EMA) can help address this need. Embedding EMA designs within established longitudinal cohorts offers a uniquely powerful approach to examine depression in both long- and short-term settings and to identify distal and proximal modifiable risk factors for…
Psychiatry
Health Informatics