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In patients with Friedreich ataxia (FA) cardiomyopathy, intravenous administration of AAVrh.10hFXN, an rh.10 serotype cardiotropic adenoassociated virus vector expressing the normal human FXN coding sequence, was well tolerated and showed promise as a potential treatment...
Details of UK Health Security Agency (UKHSA) transactions over £25,000 in 2026.
Consistent resistance training (RT) may be an important component of type 2 diabetes (T2D) prevention recommendations, especially when combined with adequate aerobic activity and limited sedentary behavior, according to a prospective cohort study published June 22 in JAMA.
Objectives Peer support is being integrated into the new maternal mental health services in England to further the development of the recovery approach in relation to loss. Psychological support after miscarriage (pregnancy loss prior to viability) is often overlooked, despite significant psychological morbidity. This systematic review explored the effectiveness of peer support interventions to improve mental health outcomes after miscarriage. Design Systematic review Data sources A comprehensive systematic search across nine databases (MEDLINE, CINAHL, APA PsycINFO, Web of Science (all…
Introduction Low-income and-middle-income countries (LMICs) contribute to the maximum burden of stillbirth globally, which affects parents in various tangible and intangible ways, emphasising the need for having a provision of parental leave to recover from the physical and mental/emotional drain. In response to this, we conducted a scoping review with the objective of identifying provision of leave within maternity benefit policies after stillbirth in LMICs. Methodology The study is conducted in accordance with Joanna Briggs Institute guidelines, using the population, concept and context…
Objective To explore which factor or combination of factors is perceived by parents as most distinctive in prompting them to seek medical care for children aged 0–5 years who were admitted to the hospital with fever due to a serious bacterial infection (SBI), in order to inform further development of an e-health tool. Design A qualitative study was conducted using semi-structured interviews with a purposive sampling strategy. Interviews were conducted by a medical intern and supervised by a clinician researcher. Interviews were audio-recorded, transcribed verbatim and analysed using thematic…
Background Acute kidney injury requiring dialysis (AKI-D) is a major contributor to morbidity and mortality worldwide, with the highest burden observed in low- and lower-middle-income countries (LLMICs). In Latin America (LATAM), a region composed largely of LLMICs, the lack of region-specific data leads to variable clinical practices and inconsistent health policies for AKI, which remain major barriers to optimal kidney care. The LATAM-AKID registry aims to fill this gap and systematically characterise the epidemiology, processes of care and outcomes of patients with AKI-D across…
Objectives To explore the characteristics of musicians with current or previous troubling musculoskeletal symptoms associated with musician self-limitation of activity (often referred to as playing-related musculoskeletal disorders (PRMSDs)), barriers and facilitators to PRMSD self-management, health needs and perspectives on digital health interventions (DHIs). The purpose of the study was to understand the unique needs of this population to effectively inform future DHIs to support this community. Design A mixed-methods study comprising an online survey and four online focus groups (2–3…
Introduction Healthcare workers (HCWs) have been disproportionately affected by the COVID-19 pandemic, both as carers and as patients. Many individuals developed persistent symptoms following an acute SARS-CoV-2 infection, known as post-COVID-19 syndrome (PCS). Previous research indicates that a significant proportion of HCWs experience long-lasting and debilitating symptoms of PCS. The aim of this study is to investigate the longitudinal symptom burden as well as the care pathways and treatment experiences of PCS-affected HCWs insured by the German Social Accident Insurance Institution for…
Introduction Sentinel lymph node biopsy (SLNB) is the standard procedure for axillary staging in clinically node-negative breast cancer. Traditionally, SLNB is performed using technetium-labelled ( 99m Tc) nanocolloid, with or without blue dye. However, both tracers have important limitations. Blue dye poses safety risks, while 99m Tc-nanocolloid introduces additional hospital visits, radiation exposure, logistical complexity and high costs. Indocyanine green (ICG) fluorescence is a non-radioactive alternative, offering real-time visualisation while addressing many limitations of traditional…
Objectives Time Together (TT) is a nursing intervention designed with a focus on increasing the possibility of patients and staff engaging in joint activities. Previous research points towards implementation difficulties but there are no studies specifically investigating the process of implementing TT in psychiatric inpatient care (PIC). Therefore, the aim of this study is to explore mid-level leaders’ and implementation leads’ perspectives on implementing TT in PIC, analysed through the Consolidated Framework for Implementation Research (CFIR). Design This qualitative study used…
Objectives This study aimed to investigate the relationship between left ventricular (LV) remodelling and systolic function in high-gradient severe aortic stenosis (AS) using cardiovascular magnetic resonance (CMR) imaging. Patients with low ejection fraction (left ventricular ejection fraction (LVEF) <50%) high-gradient severe AS (low ejection fraction high-gradient (LEF-HG)), that is, afterload mismatch, were compared with patients with normal ejection fraction high-gradient (NEF-HG) severe AS. The hypothesis of insufficient left ventricular hypertrophy (LVH) leading to high wall stress as…
Objectives To examine primary care contacts among individuals with eating disorders (EDs) and assess differences across diagnoses and ethnic backgrounds. Design Matched cohort study using retrospective primary care data. Setting Primary care electronic health records from the Clinical Practice Research Datalink (CPRD) and linked Hospital Episode Statistics (HES) covering 1 January 2010 to 31 December 2023. Participants 46 473 individuals aged 18–65 years, with a recorded ED diagnosis or a referral to ED services, matched by age, sex and practice location (ratio 1:3) to 145 286 individuals…
Objective To investigate whether the Happy Healthy Active Children (HHAC) initiative increased children’s time spent in different physical activity (PA) intensities in kindergartens located in disadvantaged neighbourhoods. Design A within-subject design, nested within the HHAC initiative, with children acting as their own controls. Setting Seven kindergartens in the adjacent disadvantaged neighbourhoods of Tingbjerg and Husum located in Copenhagen, Denmark. Participants Children aged 3–5 years attending participating kindergartens. A total of n=51 children provided valid accelerometer data…
Introduction Postural orthostatic tachycardia syndrome (POTS) is a multifactorial disorder of the autonomic nervous system characterised by an excessive increase in heart rate (HR) on standing and a wide range of debilitating symptoms, including fatigue, exercise intolerance, cognitive impairment and a high prevalence of depression, anxiety and sleep disturbances. Conventional pharmacological strategies often offer limited relief and do not sufficiently address non-cardiac symptoms. Auricular vagal neuromodulation therapy (AVNT) and slow-paced diaphragmatic breathing (SDB) have each…
Background Total hip arthroplasty (THA) is a highly effective procedure for improving pain and function in patients with advanced joint degeneration; however, revision surgery may be required because of complications or implant wear. Revision THA (rTHA) has a higher in-hospital mortality rate, longer hospital length of stay, are at higher risk of re-revision surgery and have worse physical and mental health outcome measures compared with primary THAs. The introduction of specialist revision hubs also means that patients frequently travel further for surgery. No specific guidelines have been…
Introduction Antidepressant medications are an effective treatment for major depressive disorder, yet antidepressant discontinuation early in the course of treatment remains common. Almost three-quarters of patients who are treated for depression receive their treatment exclusively from primary care providers who have relatively short visits with their depressed patients and little capacity to monitor their treatment adherence. There is a critical need to develop effective, low barrier strategies to support and promote antidepressant adherence for patients seen in primary care. We are…
Following confirmation of the first imported case of Ebola disease in Europe since the current outbreak began after a doctor returning to France from the Democratic Republic of the Congo tested positive, the European Centre for Disease Prevention and Control (ECDC) calls on EU Member States to continue strengthening their preparedness. ECDC underlines that the risk of sustained transmission within the EU/EEA is very low provided that effective measures for early detection, isolation and treatment of patients are in place.
AI adoption in healthcare isn’t being led by innovation teams, it’s the clinicians The post Keeping Up With Clinicians appeared first on MedCity News .
A series of newly planned reforms are designed to entice companies to start early trials in the U.S. rather than overseas.
Dr. Opole was recognized for years of leadership and organizational innovation as a member of the PAC.
Overseas markets are central to MiniMed’s business, accounting for 70% of reported net sales in the company’s 2026 financial year.
by Linda Chan, Wanchun Xu, Esther W. Y. Chan, Eric Yuk Fai Wan Background There is limited evidence on the use of statins for primary prevention of cardiovascular disease (CVD) in older adults with type 2 diabetes due to underrepresentation of this population in randomized controlled trials (RCTs). We aimed to determine the effectiveness and safety of statin therapy for primary CVD prevention among type 2 diabetes patients aged ≥75 years. Methods and findings In this cohort study, territory-wide electronic health records (EHRs) from the Hospital Authority Clinical Management System in Hong…
The American Diabetes Association’s Statement on Moving Civil Rights and Special Education Services mcarmody Wed, 06/24/2026 - 13:58 Official Statement The American Diabetes Association’s Statement on Moving Civil Rights and Special Education Services ARLINGTON, Va. June 24, 2026 In response to the U.S. Department of Education’s recent announcement of its intention to move oversight of civil rights to the U.S. Department of Justice and special education services to the U.S. Department of Health and Human Services, the American Diabetes Association ® (ADA) issued the following statement…