Introduction Biliary atresia (BA) is a rare but serious infantile cholangiopathy requiring timely diagnosis and surgical intervention. However, current screening methods are limited by their postnatal initiation. By contrast, antenatal imaging is increasingly considered promising due to growing evidence of a prenatal onset of BA, although high-quality diagnostic evidence remains scarce. This study aims to evaluate the diagnostic performance of antenatal biliary imaging features for the detection of BA. Methods and analysis This is a multicentre, prospective cohort diagnostic accuracy study…
Introduction Paediatric clinical education presents unique challenges for nursing students owing to the clinical complexity and emotional sensitivity of caring for ill children and their families. This high-stakes period profoundly influences students’ professional identity. This study aims to explore the lived experiences of nursing students during their paediatric practicum through a descriptive phenomenological lens. Methods and analysis This study will be conducted using a qualitative design with a descriptive phenomenological approach. Data will be collected through in-depth…
Objective Women with premenstrual disorder (PMD) display heightened sensitivity to hormonal changes and may be at risk for psychiatric disorders during other hormonally dynamic periods such as pregnancy and postpartum. While PMD has been linked to perinatal depression, associations with the full spectrum of perinatal psychiatric disorders (PNPDs), including anxiety and psychosis, remain largely unexplored. This study aimed to investigate whether a history of PMD is associated with increased risk of a first-onset PNPD. Design Nationwide register-based cohort study from 2003 to 2020. Setting…
Objectives To assess public and healthcare professional knowledge, attitudes, perceptions and behaviours regarding spatial computing technologies, virtual reality (fully immersive computer-generated environments), augmented reality (digital overlays on the physical world) and mixed reality (spatially anchored holograms) in healthcare, with a focus on perceived benefits for self-care and barriers to adoption in primary care and community settings. Design Cross-sectional online survey. Setting UK-wide, web-based survey conducted between January 2025 and August 2025. Participants…
Objective To explore healthcare professionals’ (HCPs) experiences of diagnosing cellulitis, identify unmet diagnostic needs and determine the desirable characteristics of an ideal diagnostic test. Design Qualitative study using semistructured interviews, analysed thematically. Setting Community and secondary care services across the UK from January 2023 to September 2023. Participants 25 UK-based HCPs (eg. nurses, paramedics, pharmacists, general practitioners and hospital physicians) with recent experience of managing cellulitis. Inclusion required recent involvement in cellulitis care; no…
Background Flexible bronchoscopy frequently provokes airway reflexes that impair patient comfort and procedural quality. Remimazolam provides effective sedation but often requires adjunctive opioids to suppress coughing and movement. Oliceridine is a G-protein-biased μ-opioid receptor agonist that may provide effective pain relief while minimising respiratory and haemodynamic side effects. However, the optimal dose of oliceridine combined with remimazolam for bronchoscopy remains unknown. Methods and analysis This is a prospective, single-centre, sex-stratified, up-and-down sequential…
Introduction Postoperative delirium (POD) is a prevalent perioperative complication among geriatric orthopaedic patients, leading to extended hospitalisation, escalated medical expenditures and persistent cognitive impairment. Although existing studies suggest that dexmedetomidine can reduce the risk of POD, the optimal timing of administration remains undetermined. Methods and analysis This is a prospective, randomised controlled trial. Patients aged ≥65 years undergoing lower limb fracture surgery under neuraxial anaesthesia will be randomised into a preoperative administration group, an…
Objectives This study examines awareness, perceived legitimacy, trust and readiness for the implementation of lifestyle medicine within National Health Service (NHS) prevention pathways among community-dwelling adults and healthcare professionals (HCPs) in England. A secondary objective was to assess how professional training and system factors relate to the provision and intended use of lifestyle medicine services within the NHS. Design Cross-sectional, self-administered online survey. Setting UK; online survey administered in January 2026. Participants Adults aged ≥18 years living in the…
Introduction The diagnosis and treatment of prostate cancer often disrupt patients’ and their spouses’ established family lives, requiring them to reestablish a sense of balance. This study aims to develop and evaluate a dyadic co-learning intervention derived from the activation-reinforcement-adjustment theory of family resilience for patients with prostate cancer and their spouses. Methods and analysis An experimental study design was employed. Prostate cancer patients and their spouses (n=60 pairs) will be recruited from the outpatient department. Following baseline assessment, participants…
Introduction Central venous catheters (CVCs) are essential in modern healthcare. Insertion of a CVC promotes a hypercoagulable environment, in part through activation of the intrinsic coagulation pathway. We have previously shown that blood obtained from newly inserted CVCs demonstrates immediate coagulation activation, with differences between samples collected directly after insertion and after flushing of the catheter. The aim of this randomised trial is to compare early coagulation activation between four commonly used CVCs and to assess whether the different CVCs demonstrate different…
Introduction Palliative care has been identified as one of the most inequitable areas of healthcare. In Switzerland, as globally, disparities in end-of-life care (EOLC) exist along socio-demographic lines, shaping the access to and quality of care received across services by patients and their caregivers. Research has linked these disparities to binary gender differences and other aspects of a person’s social position. The GiveCare project aims to provide a systemic understanding of how aspects of gender and diversity intersect to shape the provision of EOLC in Switzerland and to translate the…
Introduction Cognitive impairment is prevalent among adults with kidney failure treated with haemodialysis (HD). It affects multiple cognitive domains and contributes to suboptimal quality of life and clinical outcomes. Virtual reality (VR)-based cognitive training has shown benefits in various conditions including older adults without kidney failure; however, its feasibility in people receiving HD is unknown. This trial aims to evaluate the feasibility and acceptability of immersive VR cognitive training in adults undergoing maintenance HD. Methods and analysis The VIRTUAL trial is a…
Introduction Gastric intestinal metaplasia (GIM) and gastric dysplasia are critical precursors in the Correa cascade of gastric carcinogenesis. Although multiple image-enhanced endoscopy (IEE) modalities and artificial intelligence (AI)-assisted systems have been developed to improve their detection, the comparative diagnostic accuracy of these technologies remains unclear. Direct comparative studies are limited and conventional pairwise meta-analyses do not provide a coherent framework for comparing multiple diagnostic technologies. Methods and analysis This protocol follows the Preferred…
Alopexx has resuscitated its plans for a public listing as the biotech seeks urgently needed funds to advance a pipeline that includes an infectious disease antibody that was once the focus of a $375 million deal with Sanofi.
A European Medicines Agency committee now recommends withdrawing marketing authorization for Tavneos, an Amgen drug marketed in Europe by a CSL Limited subsidiary. Meanwhile, an FDA proposal to withdraw the drug from the U.S. market is set to go to a hearing. The post EMA: Amgen, Vifor Inflammatory Drug’s Benefits No Longer Outweigh Risks appeared first on MedCity News .
June 26, 2026, – La Ceiba Foods Latin Market Inc. is conducting a recall of Requesón Salvadoreño (Salvadoran Cottage Cheese) and Requesón Mexicano (Mexican Cottage Cheese) products marketed under the La Colonia and Selectos Latinos brands, due to possible contamination with Listeria monocytogenes. L
Total Nutrition Inc. of Deer Park, NY is voluntarily recalling TNVitamins 100% Organic Moringa 1,200 mg Capsules and 100% Organic Moringa Powder following a supplier-initiated recall of the raw Organic Moringa ingredient because of possible Salmonella exposure. No illnesses have been reported to dat
The Medicare Cost Cap Act seeks to create a $5,000 cap on out-of-pocket costs for traditional Medicare beneficiaries. The post New Bill Led by Democrats Aims to Cap Medicare Out-of-Pocket Costs appeared first on MedCity News .
Rural health system Reid Health is using Abridge’s AI-powered documentation tech to reduce burnout among nurses. It appears to be working — after-shift charting is down by up to 45 minutes, and the RN vacancy rate has been cut more than in half, said Misti Foust-Cofield, Reid’s chief nursing officer. The post Documentation Tools Aren’t Just for Doctors: Inside Reid Health’s Deployment of Abridge’s Nurse Tech appeared first on MedCity News .
A recent JACC review explores the growing impact of Electronic Residency Application Service (ERAS)-based signaling in cardiology fellowship recruitment, highlighting the most recent data, areas of future investigation, and practical guidance for applicants and programs.