Purpose To understand the challenges faced by family members or friends providing informal care and support to patients with low-vision glaucoma seeking treatment at the Presbyterian Hospital, Agogo in the Ashanti region of Ghana. Methods The study employed a qualitative design using semi-structured in-depth interviews to explore the lived experiences of informal caregivers of patients with low vision due to glaucoma. Participants were purposively selected at the hospital during patients’ review visits, as they accompanied them for care. Data were collected through audio-recorded interviews in…
Introduction In the past five decades, Afghanistan has experienced one of the world’s largest and most protracted displacement crises. Stressors experienced during the pre-migration, transit and post-resettlement stages of asylum-seeking and refugee journeys can trigger or exacerbate adverse mental health outcomes. More than 750 000 Afghan refugees and asylum seekers reside in high-income countries (HICs), yet no recent review has synthesised evidence on their mental health status, barriers and enablers to well-being and accessing mental healthcare, and interventions and strategies to improve…
Introduction Cancer recurrence is a pivotal outcome after treatment with curative intent for colon cancer patients, as it is related to worse survival, the subsequent need for further treatment and the associated use of healthcare resources. However, at present there is no consensus regarding the definition of locoregional recurrence of colon cancer. This contributes to variability in reporting outcomes and clinical management, limiting comparability across registries and clinical studies. This study aims to establish a consensus definition of locoregional recurrence using the Delphi method…
Introduction Rehabilitation is recognised as a cornerstone of recovery in the stroke care pathway, and the intensity of therapy is closely related to functional recovery. However, longitudinal studies investigating differences in short- and long-term outcomes between ischaemic and haemorrhagic strokes remain scarce. In particular, it is not yet clear whether atrial fibrillation-related stroke (AFRS) entails specific rehabilitation needs or leads to different functional outcomes compared with non-AFRS. Identifying aetiology-specific recovery patterns may support the development of predictive…
Introduction Prehabilitation is a promising preoperative intervention to improve patient recovery after surgery. Virtually delivered, home-based programmes represent the most efficient model for prehabilitation delivery. However, virtually delivered prehabilitation interventions remain understudied. This manuscript describes the protocol for a pilot randomised controlled trial (RCT) of a virtually monitored, home-based prehabilitation intervention. Methods and analysis We will conduct a pilot RCT comparing the standard of care to a virtually monitored home-based prehabilitation programme in…
Introduction In Great Britain, an estimated 4% of road deaths occur among children under 16 years-old. Previous research has often focused on individual-level risk factors, with less attention to the broader social, environmental and system-level determinants shaping child road safety. Emerging systematic reviews highlight the need for integrated approaches that consider inequalities, built environment characteristics and transport systems in understanding child injury risk. The establishment of the National Child Mortality Database (NCMD) in 2019 provides a unique opportunity to…
Introduction Endometrial hyperplasia (EH) is a condition that arises due to prolonged exposure of the endometrium to unopposed oestrogen, resulting in abnormal proliferation of endometrial tissue. Atypical hyperplasia, a subtype of EH, is considered a precursor lesion for endometrial cancer (EC). Polycystic ovary syndrome (PCOS) is a recognised risk factor for the development of EH and EC due to chronic anovulation and prolonged oestrogen exposure without progesterone opposition. Despite this increased risk, current clinical guidelines do not recommend routine screening for EH or EC among…
Introduction The heart and lungs are closely linked anatomically and physiologically, sharing the thoracic cavity and jointly ensuring oxygenation and removal of carbon dioxide. With the introduction of positive pressure ventilation, significant changes in cardiopulmonary dynamics were noted. Guyton described these mechanisms of reduced venous return and cardiac output via elevated right atrial pressure. Mechanical ventilation, particularly positive pressure ventilation, is widely used in paediatric critical care, yet data on its clinical effects on children’s circulation remain limited. Many…
Introduction Effective compression haemostasis is essential after transradial coronary procedures. However, evidence directly comparing different haemostatic materials remains limited. This study aims to compare and rank the efficacy and safety of different haemostatic materials used as adjuncts to compression after transradial coronary angiography and/or percutaneous coronary intervention, and to explore whether compression modality modifies their relative effects. Methods and analysis We will systematically search nine databases (Cochrane Library, Embase, PubMed, Web of Science, China…
Objectives This study aimed to develop and internally validate a neonatal mortality risk prediction model for low birthweight (LBW) neonates in public hospitals of North-West Ethiopia. Design An institution-based prospective follow-up study. Setting The study was conducted in seven hospitals, comprising three general hospitals and four primary hospitals, between 14 February and 31 October 2025. The general hospitals, Injibara, Finote Selam and Pawi, provide level II neonatal intensive care services, whereas the primary hospitals, Dangila, Chagni, Jawi and Gimja Bet, provide level I newborn…
Introduction External aortic compression is used to reduce excessive blood loss in childbirth. However, it has never been evaluated for the prevention of postpartum haemorrhage. This study aims to investigate whether routine external aortic compression, in patients undergoing elective caesarean delivery, is an effective and acceptable preventive method to reduce severe postpartum haemorrhage. Methods and analysis This multicentre, randomised, controlled, open-label trial aims to enrol 2246 patients across 10 maternity hospitals in Sweden. Patients with a live single or multiple pregnancy after…
Abivax has recovered from a dent in its share price after unveiling fresh safety data that appeared to ease investors’ concerns with its ulcerative colitis prospect.
Vistagen’s social anxiety disorder drug candidate has flunked another phase 3 trial. But, with a post hoc subpopulation analysis linking fasedienol to a nominally statistically significant improvement, the biotech plans to talk to the FDA about a path to approval built around a single future phase 3 study and confirmatory evidence from its broader PALISADE program.
American hunters skew conservative, rural, and male — all associated with increased hesitancy about or resistance to vaccines. At the same time, hunters spend more time than most people outdoors and potentially exposed to Lyme disease. So how do they feel about a potential new vaccine against the tick-borne illness?
Trinity Moravian Church, a politically diverse congregation in Winston-Salem, North Carolina, has been raising money to retire medical debt in the surrounding community.
Starting in July, the government will cap what graduate students may borrow in federal loans, forcing many toward private lenders with higher interest rates. The borrowing limits will affect students pursuing healthcare degrees, and some clinicians and student loan experts worry they may impede efforts to diversify the healthcare workforce.
This Evaluation Strategy sets out UKHSA’s organisation‑wide approach to planning, conducting and using evaluation across science, operations and public health policy.
U.S.-based Boulevard Bio is paying $20 million upfront to China’s Metis TechBio for the global rights to a trispecific T-cell engager for autoimmune diseases.
The FDA has delayed a decision on the approval of Praxis Precision Medicine’s rare epilepsy prospect by three months. TD Cowen analysts said they “strongly believe FDA bandwidth constraints from last year’s agency downsizing likely contributed to the delay.”
In the Original Investigation titled “Thiazides and Risk of Hyponatremia by Age and Sex,” published April 2, 2026, the values in the y-axes in Figures 1 and 2 were incorrect. Instead of cumulative incidences being expressed as proportions (unitless values from 0 to 1), they should be expressed as percentages. This article has been corrected.