Objectives There is growing appreciation of the role of community engagement and involvement (CEI) in designing context-specific interventions for individuals with acquired brain and spinal injuries (ABSI). This realist review evaluates CEI strategies in ABSI research in both high-income (HICs) and low- and middle-income countries (LMICs). Design A realist review. Data sources Following RAMESES guidelines, a six-stage systematic search of the following databases: Medline, EMBASE, PsycINFO and Global Index Medicus was conducted from inception to March 2025. Eligibility Studies assessing CEI in…
Objective Studies have examined the association between excess body weight and risk of cardiovascular (CV) outcomes in the general population. However, the impact of the follow-up period of excess body weight on the association between excess weight and CV outcomes is less investigated. We sought to investigate this using the UK Biobank data. Study design Population-based prospective cohort study. Setting The UK. Participants Adults aged between 40 and 69 years were recruited between 2006 and 2010. The study included 469 162 participants; the median (IQR) age was 57 (50–63) years, and 56.3% of…
Objective To investigate the association between attention-deficit/hyperactivity disorder (ADHD) and cardiometabolic risk profile at the time of type 2 diabetes (T2D) diagnosis and examine longitudinal changes in cardiometabolic measures following T2D diagnosis. Design and setting A nationwide cohort study using linked Swedish health registers. Participants Adults aged 18–65 years with a first recorded diagnosis of T2D between 1996 and 2020. ADHD, treated as a lifetime condition, was identified through diagnostic and prescription records. Outcome measures The cardiometabolic risk profile…
Objective This study aimed to find the incidence and predictors of postoperative haemodynamic instability among adult surgical patients in the postanaesthesia care unit (PACU). Study design A multicentre prospective observational study was conducted from 1 June to 30 September 2024. Setting The study was conducted at three hospitals in the South Gondar Zone, north-west Ethiopia. Participants The study included 404 elective surgical patients undergoing surgery who were in the PACU. All adult patients who were fit, stable and underwent elective surgery under anaesthesia and were admitted to the…
Objectives The study aimed to adapt the Grief Support in Healthcare Scale (GSHCS) for use in the Turkish context and evaluate its psychometric properties among nurses. Design This study is a methodological study. Setting This study was conducted in Turkey. Participants The pilot study included 30 nurses for preliminary testing and test-retest reliability. The main study comprised a convenience sample of 355 nurses. Outcome measures Content validity was evaluated by a panel of experts using the Content Validity Index (CVIs). Construct validity was assessed through exploratory factor analysis…
Objectives The impact of climate change on health is well recognised, yet its influence on postoperative complications remains underexplored. This systematic review examines how climatic factors—particularly temperature, humidity and seasonal variations—affect surgical outcomes. Design Systematic review with narrative synthesis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Data sources A comprehensive search of PubMed, Web of Science and the Cochrane Library from June 2015 to June 2025 was conducted. An additional supplementary…
Objective Sickle cell disease (SCD) is one of the most common inherited haemoglobinopathies worldwide and the most prevalent monogenic disorder in the UK. Real-world implementation of existing guidance remains variable particularly in emergency and community settings. The study aims to build national consensus among multidisciplinary stakeholders as a crucial first step towards standardising practice and improving outcomes. Design Using a single-round modified Delphi methodology, a Steering Committee of six UK-based specialists identified key domains for discussion and generated 48 consensus…
Background Due to the nature of their work, occupational fatigue is an important issue among healthcare workers (HCWs), with implications for workers’ health, patient safety and healthcare organisation performance. However, the evidence on factors of work fatigue among HCWs in Malaysia remains fragmented. Objective To synthesise the existing evidence on work fatigue among HCWs in Malaysia, with a focus on its associated factors across HCW populations and to examine the types of fatigue instruments used. Design Systematic literature review. Setting Literature on fatigue among HCWs in Malaysia…
Introduction Semen samples are commonly processed by a density gradient centrifugation method to isolate the most motile spermatozoa for fertilisation during in vitro fertilisation (IVF). Centrifugation can cause considerable damage to spermatozoa by the reactive oxygen species produced during the process, which has a negative effect on the IVF success. A microfluidic chip is an alternative sperm preparation technique using a miniaturised device containing channels and chambers in the microscale range for nanoparticle preparation. This technology enables the selection of mobile spermatozoa…
Introduction The continuous cash benefit (Benefício de Prestacão Continuada, BPC) is Brazil’s main non-contributory social pension. It guarantees a monthly income equivalent to one minimum wage to individuals aged ≥65 years and to people with disabilities living in poverty, but evidence on its health effects remains limited. This protocol describes the design and methods for evaluating the effects of BPC on hospitalisations and mortality among older adults and their household members. Methods and analysis This natural experiment study uses linked administrative records from…
Introduction Pulmonary tuberculosis (PTB) and chronic respiratory diseases (CRDs) are closely linked. Affected groups present with similar symptoms and share many risk factors (eg, poverty-related factors, smoking, occupational exposures). PTB is itself an independent risk factor for chronic lung disease. However, in many high TB-incidence settings health services for these conditions are provided separately, with little integration of prevention, diagnosis or care. Methods and analysis We describe a transdisciplinary programme of research investigating strategies for integrated TB-CRD care in…
Scribe Therapeutics is the latest biotech to prepare a public listing, as the company looks to propel its lipid-lowering medicines through clinical trials.
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Exact Imaging is looking to broaden uptake of its high-resolution micro-ultrasound system for prostate cancer screening and is boosting its commercial team to help.
Patients are to receive at least 3 weeks’ notice from the NHS for all new planned medical appointments, under plans to overhaul patients’ experiences of the health service. NHS Chief Executive, Sir Jim Mackey, today said that trying to get clarity from the NHS had been “like walking through treacle” for far too many families, […]
This guidance explains the legal framework for labelling and packaging as described in UK legislation and gives best practice for producing medicines labelling and packaging.
AstraZeneca has added another piece to its sprawling interface with CSPC Pharmaceutical, paying the Chinese biotech $30 million upfront to jointly discover and develop two kidney disease drug candidates.
Aurenar’s V-Link, a non-invasive nerve stimulation device for preventing brain hemorrhage complications, just won FDA breakthrough device designation after early trials showed it cut cerebral vasospasm by more than 40%. The post This Ear-Based Device Could Save Patients from Brain Bleed Complications appeared first on MedCity News .
FRANKLIN, Tenn., (July 2, 2026): Mars Petcare US, Inc. is issuing a voluntary recall for two lots of PEDIGREE® Can High Protein Chopped Chicken & Duck Flavor 13.2oz for dogs.