New research and findings from open-access journals and the U.S. research agencies.
This cohort study of US medical school websites examines the removal or alteration of language about diversity, equity, and inclusion at 3 time points in 2025 following legal, political, and regulatory pressures.
This cohort study investigates whether childhood exposure to public spending on community resources is associated with subsequent adult health.
Breakthrough Studies Demonstrate Effectiveness of the First Triple-Hormone Therapy for Type 2 Diabetes and Obesity mcarmody Wed, 06/03/2026 - 16:49 Press release Breakthrough Studies Demonstrate Effectiveness of the First Triple-Hormone Therapy for Type 2 Diabetes and Obesity NEW ORLEANS, La. June 6, 2026 Findings highlight use of once-weekly injection to expand potential options for weight reduction, A1C control, knee osteoarthritis, and obstructive sleep apnea First-ever type 2 diabetes and obesity phase 3 study results for retatrutide, a novel glucose-dependent insulinotropic…
Options abound for hospitals looking to capitalize on these new data transfer technologies, but so do potential pitfalls. For any hospital considering adopting these new solutions, here are some of the key questions and considerations that should be top of mind. The post New Technology is Revolutionizing Clinical Trial Data Management — Here’s How Research Hospitals Can Seize the Moment appeared first on MedCity News .
Diabetes and Endocrinology
Health Policy
This quality improvement study compares demographic characteristics and clinical outcomes among patients treated with dalbavancin for bacteremia in clinical practice vs a randomized clinical trial.
This cohort study investigates the association of olfactory groove meningioma resection with hemoglobin A1c levels and body mass index in patients with diabetes.
This randomized clinical trial evaluates the efficacy and safety of once-daily oral HRS-7535 compared with placebo among in adults in China with type 2 diabetes inadequately controlled with metformin.
by Huangdong Li, Ziyu Zhu, Shaopeng Yang, Weijing Cheng, Shaoying Tan, Zhuoyao Xin, Lei Zhang, Zhuoting Zhu, Shida Chen, Wenyong Huang, Wei Wang Background Retinal neurodegeneration is an early and independent feature of diabetic retinal disease and has been proposed as a window into the systemic neural consequences of diabetes, yet accessible molecular biomarkers and individualized prediction tools remain scarce. We aimed to identify circulating plasma protein signatures of diabetic retinal neurodegeneration (DRN) and to translate them into a clinically usable risk prediction system. Methods…
by Kelly Hughes, David Nguyen, Mason Aberoumand, Heather Ford, Erin Clarke, Nuria Banos Lopez, Margaret Dziadosz, Richard Fischer, Renato T. Souza, Jose Guilherme Cecatti, Kelly Orzechowski, Courtney Olson-Chen, Alberto Borges Peixoto, Vorapong Phupong, Joshua Rosenbloom, Moeun Son, Athena Souka, Liu Du, Michael Sean Esplin, Roberta Granese, Simi Gupta, Brenda Kazemier, Lindsay Kindinger, Pihla Kuusela, Jeanine Van der Ven, Omer Weitzner, Evelyn Minis, Alba Farras Llobet, Heather Frey, Rashmi Bagga, Siddhidatri Mishra, Elizabeth Patberg, Philip Bennett, Megan Hall, Andrew Shennan, Shaun…
by Caitlin R. Ryus, Caroline Raymond King, Edward R. Melnick The NIH 2025 Public Access Policy eliminates embargo periods for federally funded research, expanding who can read science. Yet without addressing article processing charges and market concentration, the policy risks creating new barriers to who can afford to perform and publish their science. In this Perspective, Caitlin Ryus and colleagues discuss the NIH 2025 Public Access Policy, highlighting that while expanding who can read science, the policy risks creating new barriers to who can afford to perform and publish their science.
by Lama A. Shakhshir, Alexia Karain, Jill P. Pell, Claire E. Hastie, Scott M. Nelson, Michael Fleming Background Since asthma exacerbations during pregnancy risk maternal and fetal health, continued medication is important. However, some studies have reported adverse neurodevelopmental outcomes following prenatal exposure to asthma medication. Therefore, this systematic review aimed to collate the existing evidence on the associations between prenatal exposure to asthma medication and neurodevelopmental and educational outcomes. Methods and findings A systematic review was conducted in…
by Raglan Maddox, Becky Freeman, Charlotta Pisinger, Emily Banks Contemporary tobacco and nicotine products, particularly e-cigarettes, are deliberately designed, marketed, and distributed to maximize youth appeal, uptake, dependence, and use. Youth uptake is a predictable outcome of systems designed to maximize product availability, appeal, and addictiveness. In recognition of the World No Tobacco Day 2026 theme, "unmasking the appeal", this Perspective by Raglan Maddox and colleagues discusses how tobacco and nicotine products, particularly e-cigarettes, are deliberately designed and…
by Ellen Jansen, Viki Bockstal, Florence Herschke, Per Olsson Gisleskog, Manuela Rinaldi, Angélique Boerboom, Salah Hadi, Natalia Gaibu, Michel Moutschen, Dominique Tersago Background Variable Heavy domain of Heavy chains (VHH) are innovative tools to target unique epitopes, yet few have been developed as heavy chain-only antibodies for clinical use. Rimteravimab (referred to here as XVR011) is a humanized antibody developed for the treatment of mild-to-moderate coronavirus disease 2019 (COVID-19), consisting of two identical VHHs targeting the receptor binding domain (RBD) of the severe acute…
by Wei-Xiang Qi, Shuyan Li, Mengdi Wang, Huan Li, Feifei Xu, Lei Yao, Biao Yu, Linlin Chen, Gang Cai, Cheng Xu, Xianwen Sun, Zhiyao Bao, Jiayi Chen, Yi Xiang, Shengguang Zhao Background The appropriateness of concurrent chemoradiotherapy (cCRT) for older or clinically vulnerable stage III unresectable non-small-cell lung cancer (NSCLC) patients remains contentious. Furthermore, the survival implications of de-escalating thoracic radiotherapy (RT) intensity in this population have not been conclusively elucidated. Methods and findings We conducted a phase II randomized, open-label, two-cohort…
PURPOSE Understanding and addressing increased administrative workload among family physicians is receiving attention, but data describing administrative tasks are limited. We used electronic health record (EHR) data to describe trends in orders made by family physicians, capturing changes in total workload per physician and the volume of per-patient contact over time. METHODS We used national Canadian Primary Care Sentinel Surveillance Network EHR data to measure annual counts of patient contacts, laboratory tests, referrals made, and prescriptions per physician from 2011 to 2021. We…
PURPOSE Studies of distant intercessory prayer as complementary medicine yield mixed results. We investigated commonly utilized proximal intercessory prayer (PIP) practices (ie, in-person prayer for another) used to treat pain and anxiety. METHODS We recruited 180 participants from patients waiting for family medicine appointments. Enrollment for pain required scores of 4 or greater (in the past 7 days) on an 11 point (0 to 10) pain intensity numerical rating scale. Enrollment for anxiety required a score of 10 or greater on the Generalized Anxiety Disorder 7-item (GAD-7) scale, regardless of…
PURPOSE Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem neurologic disease characterized by profound fatigue and decreased functional capacity, postexertional malaise, and unrefreshing sleep, along with cognitive impairment and/or orthostatic intolerance. Its prevalence has risen exponentially with the COVID-19 pandemic. Pharmacologic therapies have been used successfully by ME/CFS specialists but may be underused by the general medical field. METHODS To assess this potential practice gap, we retrospectively analyzed the records of 571 patients with an ME/CFS…
PURPOSE We aimed to evaluate the multicomponent School of Caring program supporting caregivers of patients with dementia with respect to caregiver burden, quality of life, emotional well-being, self-efficacy, and social support. METHODS We conducted a quasi-experimental pre-/postintervention study with a 6-month follow-up conducted in primary care in Spain. Participants were caregivers of dependent people with dementia. Sociodemographic characteristics and information regarding care tasks were collected using an ad hoc questionnaire. We evaluated the program’s effectiveness using the Zarit…
Racially and ethnically minoritized patients are underscreened for colorectal cancer (CRC), resulting in racial/ethnic disparities. This secondary analysis of a pragmatic patient-randomized clinical trial compared effects of a CRC intervention across race/ethnicity. The multicomponent intervention included a mailed fecal immunochemical test (FIT) for patients in Federally Qualified Health Centers due for screening, plus patient navigation for positive FITs. Among 3,734 patients, 9.7% identified as Hispanic, 29.0% as non-Hispanic Black, and 61.3% as non-Hispanic White, similar across…
Although older adults (>65 years of age) are considered the highest-risk population for fall-related injuries, adults with intellectual and/or developmental disability (IDD) or cerebral palsy (CP) are also at increased fall risk. We aimed to compare the incidence of fall-related emergency department (ED) visits with injury and age-related trends among adults aged 18-80 years with IDD or CP and a non-IDD/CP comparison group using the 2019 Healthcare Cost and Utilization Project State Emergency Department Databases. Fall-related ED visits with injury represented a greater proportion of ED visits…
PURPOSE Timely access to primary care remains a major challenge. Advanced access, an organizational model for appointment management, aims to improve accessibility by allowing patients to consult their health care professional in a timely manner. This systematic review evaluated its association with several key dimensions of primary care performance. METHODS We conducted a comprehensive search in MEDLINE, Embase, Web of Science, CINAHL, and the Cochrane Library from inception to May 10, 2025. Randomized intervention studies, nonrandomized intervention studies, and observational studies…