New research and findings from open-access journals and the U.S. research agencies.
Grove AI’s technology uses voice agents to recruit eligible patients for clinical trials. Formed in 2024, the startup’s rapid growth led to its acquisition by Hippocratic AI earlier this year. The post Startup to Acquisition in 2 Years: Grove AI’s Journey to Transform Clinical Trials appeared first on MedCity News .
Introduction Blunt chest trauma is frequently associated with rib fractures, and inadequate pain control may lead to respiratory complications and prolonged ventilatory support. In spontaneously breathing patients, pain impairs coughing and secretion clearance, promoting atelectasis and respiratory failure, while in mechanically ventilated patients, it may delay weaning. Current French guidelines recommend intravenous multimodal analgesia as first-line therapy followed by thoracic epidural or paravertebral block if pain remains uncontrolled. However, these techniques have limited applicability…
The FDA is allowing MMI to enroll more patients in a feasibility trial studying use of the Symani robot for microsurgery to restore drainage paths in the lymph nodes of Alzheimer's patients.
Objectives Uncertainty is inherent within medicine. Evidence-based medicine (EBM) teaching within medical curricula seeks to prepare doctors to make clinical decisions within conditions of uncertainty. The goals and scope of training for medical students and doctors are defined by published EBM competencies. We conducted a scoping review to identify the aspects of clinical uncertainty that are addressed by EBM competencies. Design A scoping review was conducted to identify and synthesise existing literature and models of clinical uncertainty, with help from an advisory group. Reported…
Introduction Following the reclassification of COVID-19 as a category V infectious disease in Japan in May 2023, systematic public health monitoring of case numbers and cluster outbreaks was discontinued. Consequently, infection control measures, responses to cluster outbreaks and vaccination coverage in long-term care facilities were largely left to the discretion of individual facilities, and the understanding of the current situation in these settings remains insufficient. This observational study aims to retrospectively investigate COVID-19 cluster outbreaks and the resulting burdens…
Objective Artificial intelligence (AI) is beginning to be used within digital surgical wound monitoring to facilitate implementation at scale. AI acceptability is essential to its success. This study aimed to explore patient and staff acceptability of an AI-based digital surgical wound monitoring platform. Design Qualitative interviews Setting Two hospitals performing cardiac surgery in England. Participants 20 patients undergoing cardiac surgery and 10 clinical staff participating in a randomised feasibility trial of surgical wound monitoring with AI. Interventions Semi-structured interviews…
Objectives To investigate the impact of government health expenditure on health outcomes in China, including its direct effects, underlying pathways and how these effects vary under different conditions of expenditure scale, health resource availability and economic development. Design A quantitative study using provincial panel data from 2008 to 2023. Analysis was conducted using a fixed-effects model, with instrumental variables employed to address potential endogeneity. A mediation model was used to examine indirect pathways and a threshold regression model was applied to explore…
Study design Multicentre randomised controlled trial. Setting Eight spinal cord injury (SCI) centres and 15 rehabilitation centres in Germany. Objectives To demonstrate the superiority of neuromuscular feedback therapy using an exoskeleton compared to conventional therapy in terms of improving walking ability in patients with chronic SCI. Methods A total of 180 patients with chronic complete or incomplete SCI and residual motor function in the lower extremities are to be included. Baseline examination will be carried out at the recruiting SCI centres, followed by 1:1 randomisation at the…
Introduction Breast cancer survivors (BCS) often experience side effects such as the fatigue, sleep disturbance and depression symptom cluster (FSDSC). Previous studies have demonstrated the potential efficacy of Tai Chi (TC) for improving FSDSC in BCS in a hospital setting in China. This study will explore the feasibility, acceptability and preliminary effects of the Easy 8 Form TC protocol as an adjuvant therapy in BC survivorship care, adapted to a regional Australian community setting. Methods and analysis The purpose of the present study is to provide a codesigned TC protocol. This…
Objectives To explore organisational opportunities for person-centred care in residential aged care facilities from the perspectives of managers and staff. Design A qualitative study using focus group discussions and inductive thematic analysis followed by a deductive interpretation guided by a theoretical framework. Setting Residential aged care facilities providing long-term care for older people in Sweden. Participants A total of 23 participants were recruited using purposive sampling and participated in five focus groups. Participants included assistant nurses, occupational therapists…
Introduction Advanced practice nurses play a vital role in addressing the growing complexity of healthcare. Although well-established internationally, advanced practice nursing in Austria remains in its early stages. The University Hospital Salzburg introduced its first advanced practice nurses in 2017, and in 2020 launched a comprehensive initiative to develop and implement advanced practice nursing roles across multiple specialties. This initiative included role development based on international frameworks, the creation of an advanced practice nurse network, scientific mentoring and an…
Objectives To explore the existing artificial intelligence (AI) tools used in the assessment and management of dysphagia. Design Scoping review. Data sources MEDLINE (Ovid), Scopus, CINAHL (EBSCOhost), Cochrane Library, Joanna Briggs Institute (JBI) Evidence Synthesis, ProQuest and Google Scholar were searched for studies published between January 2000 and May 2025. Eligibility criteria Studies involving adults diagnosed with dysphagia that applied AI techniques for screening, diagnosis, prognosis or management were included. Non-human studies, paediatric-only studies, non-clinical simulations…
Introduction Physical inactivity is highly prevalent in older adults living in deprived communities, with many living with long-term health conditions. Community-based and tailored physical activity behaviour change programmes are needed to support increased physical activity in this population. This project aims to conduct a pragmatic pre-post mixed-methods evaluation of a community-based physical activity intervention (Move Together Buckinghamshire). Methods and analysis Move Together Buckinghamshire is a 3-year community-based physical activity programme for inactive adults aged over 50…
Introduction Mpox remains an ongoing global health concern, driven by an ongoing clade I outbreak in Central Africa, which has caused substantial morbidity and mortality. Despite deployment of the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine, data on the durability of vaccine-induced immune responses remain limited, particularly in African populations, women and people with HIV, highlighting the need for context-specific immunogenicity data. Methods and analysis Mpox-Vax AFRIVAC is a prospective, multicentre observational cohort study conducted in Uganda, Tanzania and the…
Background Lactational mastitis is a common inflammatory condition that can adversely affect maternal well-being and is associated with early cessation of breastfeeding. Although antibiotics and analgesics are widely used in clinical practice, concerns regarding antimicrobial resistance and potential effects on the infant microbiome have prompted increasing interest in non-pharmacological approaches. A range of physical and biological interventions, including probiotics, therapeutic ultrasound, acupuncture and manual therapies, have been investigated; however, the comparative effectiveness and…
Introduction Afghanistan has experienced decades of war, political instability, displacement, poverty and structural upheaval, all of which are likely to have contributed to the population’s deteriorating mental health. Individual studies and reports describe depression, anxiety, trauma-related distress and a severe lack of access to care, especially among women. However, the evidence remains fragmented. There has been no recent synthesis of evidence on mental health conditions, determinants, coping strategies, services and interventions among people living in Afghanistan. This protocol…
Introduction Continuity of care with a family physician (FP) is a core attribute of effective primary care and is associated with improved health outcomes, reduced service use and lower healthcare costs. In Canada, an ageing FP workforce has led to an increasing number of patients losing their FP, raising concerns about access to care and disruptions in care trajectories. While the benefits of continuity are well documented, evidence on the consequences of discontinuity in primary care, particularly from the patient perspective, remains limited. Relational discontinuity occurs when there is a…
A phase 3 trial of Novo Nordisk’s ziltivekimab has missed its primary endpoint, denting the prospects of a molecule analysts tipped to generate blockbuster sales and diversify the company’s portfolio. Novo has chances to rescue the program with its ongoing Artemis and Hermes trials.
Public Health
Pediatrics
Pediatrics
This cohort study examines the incidence of invasive bacterial infection associated with probiotic supplementation among preterm infants.
This qualitative study compares perceptions between patients with complicated urinary tract infection and their treating clinicians about the patients’ health-related quality of life (HRQOL).
This survey study examines perceptions of safety related to firearm ownership among women in the US.