Introduction Prognostic information plays a key role in decision-making in adult intensive care units (ICUs), but its influence on advance care planning, treatment limitation and palliative-care integration depends on organisational, legal, cultural and relational factors. This review focuses on how prognostic information is used in decision-making processes. This realist review will explore how, why, for whom and in which ICU contexts prognostic information impacts care planning. Methods and analysis Following Realist and Meta-narrative Evidence Syntheses (RAMESES) publication standards for…
Background Adverse childhood experiences (ACEs) are increasingly recognised as key determinants of self-harm among adolescents, particularly within psychiatric and mental health service settings in Malaysia, where coping resources may shape vulnerability and resilience. Setting A cross-sectional study was conducted among adolescents referred to psychiatry and mental health services in Malaysia. Data and participants Of 1244 eligible patients aged 10–24 years, 1164 completed a clinician-administered, interviewer-guided questionnaire. Outcome measures Self-harm status was assessed in clinical…
Introduction Surgical site infections (SSI) impose a substantial clinical and economic burden on healthcare systems, accounting for approximately 15% of nosocomial infections. While intraoperative lavage is predominantly performed with isotonic solutions, its efficacy in preventing SSI remains unproven. Hypochlorous acid (HOCl) has emerged as a promising antimicrobial agent due to its potent microbicidal properties and high biocompatibility. The primary objective of this study is to evaluate whether the systematic introduction of a standardised intraoperative lavage with HOCl reduces the…
Background Attention-deficit/hyperactivity disorder (ADHD) is a widely recognised mental health condition that frequently persists into adulthood, significantly impacting emotional well-being, interpersonal relationships, education and employment. Adults with ADHD often report substantial psychosocial challenges, including stigma, emotional dysregulation and occupational impairment. However, current literature has primarily concentrated on clinical diagnosis, comorbidities and treatment outcomes with a disproportionate emphasis on quantitative symptom-based metrics. Consequently, there is a…
Introduction Cholecystolithiasis is a common condition and most cases are asymptomatic. In symptomatic cases, gallstone disease results in hospitalisation and significant healthcare costs. Laparoscopic cholecystectomy is the standard treatment and is traditionally performed in an inpatient setting. Recent studies indicate that outpatient laparoscopic cholecystectomy may offer comparable safety and effectiveness yet the feasibility and cost-effectiveness are not conclusively defined. Methods and analysis This randomised-controlled, open-label feasibility trial will be conducted at two surgical…
Introduction Good communication is imperative to high-quality patient care, particularly for achieving positive outcomes in healthcare consultations. Evidence about communication in clinical consultations for people with motor neurone disease (MND) is limited, but the knowledge gap prevents possible improvements to communication skills that are unique to the challenges that people living with MND encounter. This research aims to better understand and improve communication experiences for patients with MND. Methods and analysis A 24-month qualitative longitudinal study whereby data collection…
Kristoffersen EW, Fossum M, Tveit TO, et al Comparison of elective hemicolectomy patients before and after establishment of a preoperative anaesthesia assessment clinic: a retrospective, observational study in a hospital in Norway BMJ Open 2025;15:e100922. doi: 10.1136/bmjopen-2025-100922 This article has been corrected since it was published online. At the end of the Discussion section, the text currently reads: "Refuting this possibility, another study found no significant difference in the median number of days of hospital stay for patients undergoing open right hemicolectomy within an ERAS…
A phase 2b trial of Evommune’s EVO756 has missed its primary endpoint, wiping out a would-be rival to Novartis for the chronic spontaneous urticaria market.
AstraZeneca has shared the data behind previously disclosed phase 3 rare disease wins, fleshing out the case for a Strensiq successor tipped to generate blockbuster sales. The company has yet to share data from a third trial that missed its primary endpoint.
Background: Whether sedative prescriptions after hospital admissions are associated with poor patient outcomes is unknown. We sought to determine the incidence and risk of adverse events associated with sedatives in older adults within 30 days after hospital discharge. Methods: We conducted a population-based cohort study involving older adults (age ≥ 66 yr) discharged alive from hospital in Ontario (2003 to 2023). We assessed the association of sedative prescriptions (benzodiazepines, antidepressant sedatives, or antipsychotics) filled within 7 days after discharge with falls (with or…
In the Original Investigation titled “Pharmacologic Thromboprophylaxis in Medical Inpatients: A Systematic Review and Network Meta-Analysis,” published May 15, 2026, Laura Girardi’s academic degree was incorrectly listed as PhD instead of MD in the author byline. This article has been corrected.
The Original Investigation titled “Bidirectional Association Between Premenstrual Disorders and Psychiatric Disorders,” published on May 8, 2026, was corrected to fix wording in the Abstract Results, which now states that women with PMD were twice as likely as women without PMD to receive a subsequent psychiatric disorder diagnosis. This article was corrected online.
This cross-sectional study assesses the prevalence and associated characteristics of registered studies related to suicidal thoughts and behaviors that have been discontinued.
This cohort study examines the association of cardiovascular health during pregnancy, assessed using a modified Life’s Essential 8 score, with time to incident cardiometabolic disease.
This cohort study evaluates the incidence of and factors associated with hospital readmission and late mortality after discharge among children undergoing surgical repair of congenital diaphragmatic hernia.
This cohort study characterizes treatment patterns and attrition rates in a contemporary dataset of patients with metastatic castration-resistant prostate cancer to understand how these therapies are used in clinical practice.
This cross-sectional study of children aged 2 weeks through 10 years estimates optimal and reference threshold curves for pediatric hemoglobin levels, expressed as a continuous function of age.
This diagnostic study compares the ability of 6 different large language models (LLMs) to identify missed opportunities for diagnosis among patients admitted to emergency departments (EDs) that use electronic trigger (eTrigger) tools for quality and safety surveillance.