New research and findings from open-access journals and the U.S. research agencies.
Roche’s investigational KRAS G12C inhibitor has beaten Amgen’s Lumakras and Bristol Myers Squibb’s Krazati in a phase 3 trial, furthering its ambitions to establish divarasib as a new standard of care.
FDA approval of Orca Bio’s Tregzi makes it the first cell therapy based on regulatory T cells, or Tregs. Clinical trial results showed reduced risk of graft-versus-host disease, a common complication of the allogeneic stem cell transplants that are a standard treatment for certain blood cancers. The post Orca Bio Cell Therapy Gets Landmark FDA Nod for New Kind of Living Medicine appeared first on MedCity News .
On behalf of my coauthors, I write to request retraction our Original Investigation, “Personality Traits and Social Isolation in Older Adults,” published in JAMA Network Open on May 6, 2026. This study used data from National Health and Aging Trends Study (NHATS). We acknowledge that we did not obtain the NHATS dataset directly through the authorized application and approval process stipulated by the data stewardship team. Instead, we used raw data files that were shared with us by a third party, without verifying that this mode of access adhered to NHATS’s official terms of use. This…
In the Original Investigation titled “Job Flexibility, Job Security, and Mental Health Among US Working Adults,” published March 25, 2024, the grant number from the Community Engagement Alliance Against COVID-19 Disparities was incorrect. The grant number was originally listed as 10T2HL156812-01 and should have been listed as OT2HL158287. This article has been corrected.
Geriatrics
This cohort study examines associations of urbanicity with dementia mortality, quantifies the extent to which neighborhood socioeconomic and environmental factors attenuate these associations, and estimates potential deaths averted under feasible improvements in modifiable conditions.
This systematic review and meta-analysis of studies of US veterans receiving cancer care through the Veterans Health Administration compares outcomes for Black veterans compared with veterans from other racial groups.
This case-control study investigates compares limbic system microstructure in neonates with vs without opioid exposure.
This systematic review and meta-analysis examines factors associated with risk of suicide mortality in individuals aged 24 years and younger.
This cross-sectional study provides US national estimates and investigates the characteristics of older adults who receive care from friends vs family caregivers.
This cohort study investigates associations between the 2024 to 2025 trainee physician walkout and mortality, health care usage, and spending patterns in South Korea.
This case-control study uses Danish registry data to examine whether different progestogens used as hormonal contraception are associated with risk of meningiomas.
Same-day coadministration of COVID-19 and influenza vaccines was not associated with an increased risk for adverse events in 3 updated-formulation periods. These findings support the short-term safety of coadministration.
Merck & Co. has nixed the phase 2 study of a potential Alzheimer’s disease medicine after the drug underwhelmed in an interim analysis, marking another blow for the pharma’s struggling partner Neuphoria Therapeutics.
Objectives Prognostic uncertainty is common in advanced illness, driven by multimorbidity, treatment complexities and unpredictable disease trajectories. When inadequately acknowledged or discussed, it can lead to patient and family distress and inhibit decision-making. We aimed to build a programme theory of how, why and for whom communication of prognostic uncertainty ‘works’ (or not) in advanced illness and palliative care contexts. Design Realist systematic review, reported according to RAMESES criteria. Data sources Embase, MEDLINE, CINAHL, Cochrane Database of Systematic Reviews, SCI via…
The 2026 Society for Cardiovascular Angiography and Interventions (SCAI) Scientific Sessions and CAIC-ACCI Summit, held in Montréal, Canada, highlighted the continuing evolution of interventional cardiology through the presentation of several important late-breaking clinical trials.
Objectives The main objective of this study is to assess the temporal distribution of taluk (sub-district)-level maternal mortality trends within Karnataka and identify the hotspots and medical and non-medical factors that were significantly contributing to maternal deaths. Design Spatial patterns and determinants of maternal mortality were investigated using a retrospective ecological study design. Data source Maternal mortality data were collected from the Directorate of Health and Family Welfare Services, Government of Karnataka, while political boundaries of state, districts and taluks…
Objectives Iron deficiency (ID) is frequent in heart failure (HF). Among patients with HF and ID, those with impaired iron transport (IIT) (transferrin saturation (TSAT) <20%) have the worst ID phenotype. In HF, exercise limitation is mainly related to abnormality in oxygen delivery (VO 2 ) and utilisation and/or to ventilation inefficiency. We evaluated whether it is possible to identify the leading cause of exercise limitation in patients with HF and IIT. Design Observational study. Setting Retrospective study. Participants We analysed 1043 consecutive hospitalised patients with HF…
Introduction Spondyloarthritis (SpA) comprises a heterogeneous group of chronic inflammatory diseases. Axial SpA (axSpA) predominantly involves the sacroiliac joints and the spine and typically presents with back pain and stiffness. Modern imaging techniques, especially MRI, allow earlier detection of axSpA compared to conventional radiography, but imaging findings still need cautious interpretation to facilitate a clinical diagnosis. This cohort study of patients with suspected SpA is designed to (1) compare demographic, clinical, laboratory, imaging data and patient-reported outcomes (PROs)…
Introduction Child marriage remains a pressing social and public health issue globally, with significant implications for the rights, well-being and development of affected individuals. In Iran, legal frameworks that permit marriage from as young as 9 lunar years for girls—despite countervailing influences such as rising education levels and social reforms—have failed to curb the persistence of early marriage, which continues to be driven by entrenched cultural, socioeconomic and legal factors. Understanding the multifaceted nature of child marriage within this context is crucial for…
Introduction Psychotic disorders account for significant morbidity and healthcare costs and yet their pathophysiology remains poorly understood. The National Institute for Health and Care Research (NIHR) Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource is a collaborative project that aims to collect clinical data and biological samples from people with psychosis for long-term storage, future projects and recontact for targeted trials. Methods and analysis The NIHR SMILE BioResource cohort will initially include up to 2000 UK-based patients with a recorded diagnosis of…
Objectives To investigate the association between drinking-water sodium concentration and blood pressure among non-pregnant women living in a high-salinity, climate-vulnerable coastal region of Bangladesh. Design Follow-up study of women originally enrolled in a population-based study conducted during pregnancy between 2009 and 2011. Setting Rural coastal subdistrict in southwest Bangladesh affected by saltwater intrusion and seasonal drinking-water insecurity. Participants Of 1208 women enrolled in the original study, 900 were located in 2018 and 740 non-pregnant women were re-enrolled and…
Introduction Artificial intelligence (AI) is increasingly used in tuberculosis (TB) diagnosis, but its clinical adoption depends not only on accuracy but also on physicians’ trust and understanding of AI outputs. Explainable AI (XAI) has been proposed to address this challenge, but limited evidence exists on which explanation features are most valued by physicians in TB diagnostic settings. Discrete choice experiments (DCEs) offer a structured method to elicit physicians’ preferences and quantify trade-offs among explainability attributes. This protocol describes a DCE designed to examine TB…
Objectives To explore refill adherence to prescribed treatment for chronic heart failure (CHF) and/or chronic obstructive pulmonary disease (COPD), during and after a remote person-centred care (PCC) intervention. Design Post hoc analysis of a randomised controlled trial cohort. Setting We used data from the PROTECT (Person-Centred Care at Distance) randomised controlled trial in Swedish primary care, which were linked to data from the Swedish Prescribed Drug Register. Participants A total of 222 participants from nine primary care centres were enrolled in PROTECT. This study included…