New research and findings from open-access journals and the U.S. research agencies.
This crossover trial evaluates whether N-of-1 deprescribing trials can identify older men who are receiving minimal benefit from tamsulosin therapy for lower urinary tract symptoms.
This cohort study examines differences in health care utilization and spending among Medicare beneficiaries with vs without a COVID-19 diagnosis.
This cohort study analyzes associations of prostate-specific antigen testing practices with incidence of metastatic prostate cancer among US veterans.
This randomized crossover trial examines whether sequential cerebellar transcranial magnetic stimulation and striatal transcranial temporal interference stimulation enhance working memory in individuals with mild cognitive impairment (MCI).
PureTech Health spinout Celea Therapeutics will apply the financing toward a Phase 3 test of its idiopathic pulmonary (IPF) drug, deupirfenidone. The pivotal study will test the oral small molecule head-to-head against a standard of care IPF drug. The post Lung-Focused Celea Secures $180M for Pivotal Test of Pulmonary Fibrosis Drug appeared first on MedCity News .
Background Although solid organ transplantation is a life-saving procedure, it is also associated with numerous challenges for patients. Creative writing has been described as a therapeutic tool for patients with chronic disease. Between 2020 and 2022, we held creative writing workshops with patients and professional writers. During these workshops, patients were invited to explore different aspects of their transplantation journey through different literary styles. Objectives The aim of this study is to understand lung, liver and heart transplant patients’ perspectives on the role of patient…
Introduction Innovative clinical trials, including adaptive and Bayesian designs, can improve efficiency and prioritise patient-centric approaches. Despite their recognised advantages, the global adoption of innovative clinical trial designs remains uneven, with substantial variation observed across socioeconomic and gender-related contexts. This study investigates the global distribution of innovative trial designs and their association with the Inequality-adjusted Human Development Index (IHDI) and Gender Inequality Index (GII). Methods We conducted a cross-sectional observational analysis…
Objectives To determine whether the onset of physical health problems/sensory impairments is associated with incident challenging behaviours. Design A retrospective, population-based cohort study using longitudinal data from primary care records. HRs were estimated using Cox proportional hazards models accounting for recurrent events and time-varying exposures. Setting UK primary care data sourced from the Clinical Practice Research Datalink (CPRD) Aurum and Gold databases, covering over 850 000 person-years between 2009 and 2019. Participants 166 989 individuals with recorded intellectual…
Purpose The Sheyang Mini Birth Cohort Study (SMBCS) aimed to assess the impact of prenatal and postnatal environmental factors on children’s development. Participants SMBCS was established in Sheyang County, Jiangsu Province, China. Between June 2009 and January 2010, 1303 healthy pregnant women residing in Sheyang for at least 1 year were recruited along with their 1312 newborns. By 2025, the SMBCS had completed 11 follow-up rounds covering children ages 1–16, with a total of 4696 postnatal visits. Questionnaire interviews, physical examinations, neurodevelopmental and pubertal assessments…
Introduction Non-attendance to healthcare appointments among young people with long-term conditions (LTCs) presents significant challenges to continuity of care and clinical outcomes. Although factors associated with non-attendance have been explored in broader populations, there remains an evidence gap concerning the specific drivers among adolescents and young adults aged 10–24 years living with chronic physical or mental health conditions. This review aims to identify and synthesise factors associated with healthcare appointment non-attendance among young people with LTCs. Methods and…
Objectives There is growing appreciation of the role of community engagement and involvement (CEI) in designing context-specific interventions for individuals with acquired brain and spinal injuries (ABSI). This realist review evaluates CEI strategies in ABSI research in both high-income (HICs) and low- and middle-income countries (LMICs). Design A realist review. Data sources Following RAMESES guidelines, a six-stage systematic search of the following databases: Medline, EMBASE, PsycINFO and Global Index Medicus was conducted from inception to March 2025. Eligibility Studies assessing CEI in…
Objective Studies have examined the association between excess body weight and risk of cardiovascular (CV) outcomes in the general population. However, the impact of the follow-up period of excess body weight on the association between excess weight and CV outcomes is less investigated. We sought to investigate this using the UK Biobank data. Study design Population-based prospective cohort study. Setting The UK. Participants Adults aged between 40 and 69 years were recruited between 2006 and 2010. The study included 469 162 participants; the median (IQR) age was 57 (50–63) years, and 56.3% of…
Objective To investigate the association between attention-deficit/hyperactivity disorder (ADHD) and cardiometabolic risk profile at the time of type 2 diabetes (T2D) diagnosis and examine longitudinal changes in cardiometabolic measures following T2D diagnosis. Design and setting A nationwide cohort study using linked Swedish health registers. Participants Adults aged 18–65 years with a first recorded diagnosis of T2D between 1996 and 2020. ADHD, treated as a lifetime condition, was identified through diagnostic and prescription records. Outcome measures The cardiometabolic risk profile…
Objective This study aimed to find the incidence and predictors of postoperative haemodynamic instability among adult surgical patients in the postanaesthesia care unit (PACU). Study design A multicentre prospective observational study was conducted from 1 June to 30 September 2024. Setting The study was conducted at three hospitals in the South Gondar Zone, north-west Ethiopia. Participants The study included 404 elective surgical patients undergoing surgery who were in the PACU. All adult patients who were fit, stable and underwent elective surgery under anaesthesia and were admitted to the…
Objectives The study aimed to adapt the Grief Support in Healthcare Scale (GSHCS) for use in the Turkish context and evaluate its psychometric properties among nurses. Design This study is a methodological study. Setting This study was conducted in Turkey. Participants The pilot study included 30 nurses for preliminary testing and test-retest reliability. The main study comprised a convenience sample of 355 nurses. Outcome measures Content validity was evaluated by a panel of experts using the Content Validity Index (CVIs). Construct validity was assessed through exploratory factor analysis…
Objectives The impact of climate change on health is well recognised, yet its influence on postoperative complications remains underexplored. This systematic review examines how climatic factors—particularly temperature, humidity and seasonal variations—affect surgical outcomes. Design Systematic review with narrative synthesis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Data sources A comprehensive search of PubMed, Web of Science and the Cochrane Library from June 2015 to June 2025 was conducted. An additional supplementary…
Objective Sickle cell disease (SCD) is one of the most common inherited haemoglobinopathies worldwide and the most prevalent monogenic disorder in the UK. Real-world implementation of existing guidance remains variable particularly in emergency and community settings. The study aims to build national consensus among multidisciplinary stakeholders as a crucial first step towards standardising practice and improving outcomes. Design Using a single-round modified Delphi methodology, a Steering Committee of six UK-based specialists identified key domains for discussion and generated 48 consensus…
Background Due to the nature of their work, occupational fatigue is an important issue among healthcare workers (HCWs), with implications for workers’ health, patient safety and healthcare organisation performance. However, the evidence on factors of work fatigue among HCWs in Malaysia remains fragmented. Objective To synthesise the existing evidence on work fatigue among HCWs in Malaysia, with a focus on its associated factors across HCW populations and to examine the types of fatigue instruments used. Design Systematic literature review. Setting Literature on fatigue among HCWs in Malaysia…
Introduction Semen samples are commonly processed by a density gradient centrifugation method to isolate the most motile spermatozoa for fertilisation during in vitro fertilisation (IVF). Centrifugation can cause considerable damage to spermatozoa by the reactive oxygen species produced during the process, which has a negative effect on the IVF success. A microfluidic chip is an alternative sperm preparation technique using a miniaturised device containing channels and chambers in the microscale range for nanoparticle preparation. This technology enables the selection of mobile spermatozoa…
Introduction The continuous cash benefit (Benefício de Prestacão Continuada, BPC) is Brazil’s main non-contributory social pension. It guarantees a monthly income equivalent to one minimum wage to individuals aged ≥65 years and to people with disabilities living in poverty, but evidence on its health effects remains limited. This protocol describes the design and methods for evaluating the effects of BPC on hospitalisations and mortality among older adults and their household members. Methods and analysis This natural experiment study uses linked administrative records from…
Introduction Pulmonary tuberculosis (PTB) and chronic respiratory diseases (CRDs) are closely linked. Affected groups present with similar symptoms and share many risk factors (eg, poverty-related factors, smoking, occupational exposures). PTB is itself an independent risk factor for chronic lung disease. However, in many high TB-incidence settings health services for these conditions are provided separately, with little integration of prevention, diagnosis or care. Methods and analysis We describe a transdisciplinary programme of research investigating strategies for integrated TB-CRD care in…
Scribe Therapeutics is the latest biotech to prepare a public listing, as the company looks to propel its lipid-lowering medicines through clinical trials.
Roche’s divarasib was designed offer greater potency and selectivity to KRAS G12C compared to first-generation drugs in this class marketed by Amgen and Bristol Myers Squibb. The Swiss pharma company now plans to submit the data to regulators for review as a potential treatment for non-small cell lung cancer driven by this particular mutated protein. The post With New Phase 3 Data, Roche Claims an Edge Over Amgen and BMS Lung Cancer Drugs appeared first on MedCity News .
by Muhammad Zakir Hossin, Anne Gadermann, Edit Nagy, Randip Gill, Monique Gagné Petteni, Jonas Faxén, Neda Razaz Background While maternal congenital heart disease (CHD) is associated with increased risks of adverse pregnancy outcomes, its impact on long-term child development remains unknown. This study aimed to investigate if in-utero exposure to maternal CHD is associated with child developmental vulnerability at school entry. Methods and findings This population-based cohort study included 256,629 singleton offspring born in British Columbia, Canada between January 1, 1995 and December 31…