New research and findings from open-access journals and the U.S. research agencies.
This cross-sectional study examines what percentage of mental health treatment facilities in the US offer telehealth services for children and what factors are associated with offering any telehealth services and medication management via telehealth.
In this interview, Matthew Martinez, MD, FACC and Steven E. Nissen, MD, MACC examine the SURPASS-CVOT Randomized Clinical Trial.
by Anthony Muchai Manyara, Suad Abdullah, Ayaan Balshaf, Tadios Manyanga, Momodou Jallow, Etheldreda I. Yoliswa Madela, Hannah Wilson, Anya Burton, Farhanah Paruk, Chris Grundy, Camille Pearse, Tafadzwa Madanhire, Lucy Gates, Bilkish Cassim, Rashida A. Ferrand, Kate A. Ward, Celia L. Gregson Background Hypertension and diabetes prevalence are increasing across Africa. We investigated the prevalence, associated factors, achievement of stages within the care cascade (diagnosis, treatment, control), and health-related quality of life (HRQoL) in three countries in Africa. Methods and findings This…
by Liyuan Chen, Jiaxing Song, Changwei Guo, Linyu Li, Tao Xu, Chen Gong, Liping Huang, Shuyu Jiang, Lin Gao, Xinyu Li, Gang Wu, Xue Wang, Thanh N. Nguyen, Jeffrey L. Saver, Yangmei Chen, Wenjie Zi, Chang Liu Background Cardiac complications rank among the leading contributors to poor outcomes in ischemic stroke patients along with the neurological impairment, while the risk stratification and prognostic significance of post-stroke acute heart failure (PSHF) remain poorly characterized. This study aimed to investigate the incidence, predictors, and impacts of PSHF in patients with large vessel…
Introduction Mental health is an urgent public health issue with social and economic relevance. Business families play a key economic role, yet their specific mental health challenges remain underexplored. High performance expectations, succession pressures and the wish for discretion may obscure psychological stress. The WIFU-GESUND study addresses this gap by conducting the first representative mental health survey among adult members of business families in Germany. Methods and analysis This cross-sectional study targets adults with legal ownership in German family businesses. A…
Introduction Tribal people in India face a growing risk of multimorbidity, primarily from cardiovascular diseases (CVD) due to changing lifestyles and unique socio-cultural and political factors. We aimed to identify treatment patterns and barriers to medication adherence for CVD. This will inform culturally sensitive implementation strategies that may improve outcomes among tribal communities. Methods We conducted an exploratory cross-sectional study among participants with multimorbidity in a South-Indian tribal setting. We used a structured questionnaire, guided by the Consolidated…
Purpose The Guangxi Eco-Environmental Health and Aging Study (GEHAS) was established to investigate the interplay between eco-environmental exposome, multi-omics profiles, and healthy ageing in a multi-ethnic subtropical population. This prospective cohort was designed to address knowledge gaps regarding how eco-environmental and lifestyle factors influence ageing trajectories. Participants GEHAS enrolled 5645 participants (59.8% women; mean age 62.51 years) from Guilin, Guangxi, at baseline, with Yao and Han participants accounting for 60.3% and 36.2% of the cohort, respectively. Baseline…
Objectives Scarce surgical capacity makes prioritisation decisions unavoidable. During crises, the complexity and societal sensitivity of such decisions become particularly evident, underscoring the importance of engaging multiple stakeholders, including citizens. Citizens may hold different preferences and attach importance to different considerations than physicians regarding what is fair or appropriate when allocating scarce surgical capacity. This study, therefore, examined which preferences and considerations citizens consider important in decisions about prioritising patients for limited…
Introduction Percutaneous coronary intervention (PCI) has evolved significantly over the past decade with approximately 30% of patients presenting with complex coronary artery disease, posing heightened procedural and long-term risks. Complexity in PCI is increasingly recognised as multifactorial, encompassing lesion, procedural and patient-related characteristics. The Ultimaster Nagomi sirolimus-eluting coronary stent system is designed to address the challenges of complex PCI. The NAGOMI COMPLEX study aims to assess its safety and clinical performance in a comprehensively defined complex PCI…
Objectives To explore, from the perspective of patients with stable coronary artery disease (SCAD), their perspectives and experiences of shared decision-making (SDM) participation. Design A descriptive qualitative research design was adopted in this study. The reflexive thematic analysis method was used to generate themes. Setting The study was conducted at a grade III level A hospital in Hangzhou, Zhejiang Province, China. The main interview locations for this study were quiet wards, meeting rooms and the respondents’ residences. Participants Between January and April 2025, 15 patients with…
Objective Neighbourhood socioeconomic status (nSES) and built environment features strongly influence diet, physical activity and cancer screening adherence, potentially affecting colorectal cancer (CRC) incidence and prognosis. The aim of this study is to assess the association between neighbourhood obesogenic environments (eg, nSES, restaurant and retail food indices, recreational facilities, and business district residence) and CRC risk and mortality. Design A secondary data analysis was performed using prospectively collected data from the Southern Community Cohort Study. Setting 12 states…
Introduction Patients with metastatic renal cell carcinoma (mRCC) treated with immune checkpoint inhibitors (ICIs) may experience immune-confirmed stable disease (iSD) or progressive disease (iCPD). Abscopal responses following ultra-hypofractionated radiotherapy during immunotherapy have been reported, but their incidence, timing and associated clinical or biological factors remain poorly defined in prospective observational settings. Methods and analysis AURICRE is a prospective, multicentre observational study that plans to enrol 145 patients with mRCC who exhibit iSD or iCPD during ongoing…
Introduction Children born extremely preterm (EP; <28 weeks’ gestation) and/or extremely low birth weight (ELBW; <1000 g) are at increased risk of difficulties across a range of neurodevelopmental domains and respiratory outcomes long term. The Victorian Infant Collaborative Study (VICS) in Australia has tracked detailed perinatal and developmental outcomes across four distinct EP/ELBW birth cohorts: 1991–1992, 1997, 2005 and 2016–2017. Improvements in 2-year developmental outcomes were reported in the VICS 2016–2017 cohort compared with previous eras; however, whether these improvements are…
Introduction Rapid sequence induction (RSI) is widely used in patients at risk of pulmonary aspiration but may be associated with haemodynamic instability and intubation difficulties. It remains unclear whether patients with moderately increased risk of aspiration benefit from RSI compared with standard induction including mask ventilation. Methods and analysis This multicentre, randomised, controlled, parallel-group, patient-blinded trial will enrol 792 adult surgical patients with moderately increased risk of aspiration. Participants will be randomised 1:1 to RSI (no mask ventilation…
Phase 3 trials of Kailera Therapeutics’ oral GLP-1 prospect have hit their primary endpoints, positioning the biotech’s partner Hengrui Pharma to seek approval in obesity and diabetes in China.
Psychiatry
Obstetrics and Gynecology
Health Informatics
This randomized clinical trial evaluates the effectiveness of hospital-based assertive case management as an adjunct to standard psychiatric treatment for patients with major depressive disorder presenting with suicidal ideation.
This cohort study estimates the incidence of recurrent invasive pneumococcal disease among adult patients in Canada and assesses risk factors for recurrence among patients with a primary episode of invasive pneumococcal disease.
This cohort study examines pain trajectories and patterns of opioid and nonopioid treatment use among opioid-naive patients who were offered an opioid prescription for acute pain in a variety of clinical settings.
This nonrandomized clinical trial evaluates the association of interval salpingectomy with delayed oophorectomy vs risk-reducing salpingo-oophorectomy for ovarian cancer prevention with sexual function and menopausal symptoms.
This survey study reports on how US adolescents perceive risk related to different levels of fentanyl use.
This qualitative study examines patient perspectives about messages drafted by artificial intelligence (AI) in online patient portals to identify implications for patient-centered implementation.