New research and findings from open-access journals and the U.S. research agencies.
Cardiovascular-kidney-metabolic (CKM) syndrome is associated with incremental cancer risk and stage-specific immune-metabolic pathways, according to a study using data from the UK Biobank published July 16 in JACC: CardioOncology. These findings highlight potential prevention targets.
The purposes of eligibility criteria for cancer clinical trials are to select the intended patient population and reduce potential risks to trial subjects.
The purposes of eligibility criteria for cancer clinical trials are to select the intended patient population and reduce potential risks to trial subjects.
Guidance for Industry, IRBs, and Clinical Investigators
by Josephine Hegarty, Ismail Toygar, Maria Inês Clara, Ewa Pawlowska Many assumptions around patient needs and support guide current oncology practice and cancer survivorship care in the digital era. Addressing these assumptions and providing smarter, holistic, tech-enabled follow-up models are essential for truly effective and sustainable person-centered care.
Objective To codesign a preclinic Diabetes Priorities Questionnaire (DPQ) tool for people with type 2 diabetes and healthcare professionals to identify patient needs in advance and enable efficient, patient-centred consultations for diabetes management. Design Participatory approach using codesign focus groups to explore perspectives and develop solutions. Setting This study was conducted in Western Sydney, Australia, an area with high socioeconomic disadvantage and cultural diversity. Participants 10 adults with type 2 diabetes and 8 healthcare providers including specialists, diabetes…
Abstract Objectives To explore families’ experiences of deceased organ donation and examine the perceived influence of participation in the donation process on grief and bereavement in Spain. Design Qualitative study with a phenomenological orientation, conducted as the qualitative component of a broader mixed-method prospective cohort study, using semi-structured interviews and thematic analysis informed by an abductive approach. Setting The study was conducted in Spain with relatives of patients declared dead by neurological or circulatory criteria following potential deceased organ donation…
Objectives To estimate the prevalence of potentially inappropriate prescribing (PIP) in UK middle-aged adults, identify patient-level factors associated with PIP and its associations with subsequent primary care utilisation and mortality. Design A prospective observational cohort study. Setting English routinely collected primary care electronic health record data from the Clinical Practice Research Datalink Aurum. The follow-up period was from 1 January 2018 to 7 February 2023. Participants Randomly selected individuals (n=1 200 000) who were aged 45–64 years on 1 January 2018. Exposure…
Objective Financial toxicity (FT) poses a major challenge in cancer treatment. This study aimed to explore oncologists’ attitudes towards FT, the barriers they face in managing it and potential solutions. Design The study employed an exploratory qualitative design using inductive thematic analysis. Setting The study was conducted at two tertiary care hospitals in Bahawalpur, Pakistan. Participants Thirteen oncologists were approached; 12 participated. Purposive sampling was used to select the participants. Eligible participants were all licensed oncologists who signed a written consent form…
Introduction Community-acquired pneumonia (CAP) is common and remains the leading infectious cause of death worldwide. Antibiotics remain the mainstay of treatment, but organisms are often not identified, necessitating empirical treatment. Current treatment guidelines recommend combination therapy with beta-lactams and macrolides or monotherapy with fluoroquinolones for non-severe CAP. However, rising antibiotic resistance and safety concerns have led to increased doxycycline use, despite limited evidence supporting its efficacy. Our goal is to conduct a pragmatic, open-label, randomised…
Introduction MR enterography (MRE) and intestinal ultrasound (IUS) are used to assess therapeutic response in Crohn’s disease (CD) follow-up. There is, however, no clear guidance regarding which modality should be used for individual patients or if they are interchangeable. Therefore, clinical practice varies. We will compare the accuracy of MRE and IUS to classify treatment response in CD. Methods and analysis Multicentre, non-randomised, multiple arm, prospective cohort study of luminal CD patients aged 16 years or older being treated with steroids, immunomodulators, biologics/biosimilars or…
Introduction Thoracic paravertebral block (PVB) is widely used for analgesia but carries risks such as pneumothorax and hypotension. Intertransverse process block (ITPB) is a newer alternative that may offer comparable analgesia with a potentially improved safety profile. However, few studies have compared the two from the patient’s perspective, and none have assessed ultrasound-guided ITPB against PVB for postoperative recovery quality in elderly patients. Methods and analysis This two-centre, double-blind, parallel-group, randomised controlled trial will enrol 152 elderly patients (age…
Objectives The objective of this study is to explore the lived experiences of triage nurses. Primary and secondary outcomes The primary and secondary outcomes are the identification of barriers and facilitators that influence effective triage practice in a tertiary care centre in a low- and middle-income country. Design A qualitative phenomenological study was conducted, grounded in a realistic ontology, which assumes that reality is subjective and constructed through individual experiences. Semi-structured interviews were conducted with nursing staff until data saturation was achieved…
Introduction Healthcare systems face increasing strain from population ageing, multimorbidity and rising emergency department (ED) attendances. Acute medical units (AMUs) have been adopted internationally to improve patient flow and reduce hospital length of stay, but prospective evidence on their clinical and economic effectiveness remains limited, particularly in Singapore. This study aims to evaluate the clinical outcomes and cost-effectiveness of an AMU model compared with usual care in the general ward at a Singapore tertiary hospital. Methods and analysis This is an ongoing single-centre…
Introduction Cardiovascular disease (CVD) remains a leading cause of preventable morbidity and mortality. Most existing CVD prediction tools use a baseline survival modelling framework, in which each predictor is represented by a single value recorded at the start of follow-up. Although risk calculators can be re-run using updated values, these models do not explicitly use the longitudinal, irregularly recorded information in primary-care electronic medical records (EMRs). Dynamic modelling approaches have the potential to generate updated CVD risk estimates at each general practitioner (GP)…
MapLight Therapeutics’ stock plummeted more than 60% this morning after the neuro outfit dropped mixed results for a phase 2 trial of its experimental schizophrenia treatment.
InnoCare Pharma announced Monday that its oral tyrosine kinase 2 (TYK2) inhibitor fadeucravacitinib met the primary endpoint in a phase 3 trial of adults with moderate-to-severe plaque psoriasis.