Uncomplicated UTI (cystitis) in women
What the major U.S. guidelines recommend, with a link to verify each at the source. A quick-reference summary for clinicians, not medical advice.
IDSA · 2011
First-line for uncomplicated cystitis: nitrofurantoin x5d, TMP-SMX x3d (if local resistance <20% and no recent use), or fosfomycin single dose. Avoid fluoroquinolones first-line (reserve for pyelonephritis).
Verify at IDSA →AUA/CUA/SUFU · 2025
Recurrent UTI: offer non-antibiotic prophylaxis (cranberry; methenamine hippurate; increased water intake if below 1.5 L/day). D-mannose alone may not be effective. May offer patient-initiated (self-start) therapy in select patients while awaiting cultures. Do not perform post-treatment test-of-cure urinalysis or culture in asymptomatic patients.
Verify at AUA/CUA/SUFU →