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Statins for primary prevention

What the major U.S. guidelines recommend, with a link to verify each at the source. A quick-reference summary for clinicians, not medical advice.

USPSTF · 2022 · Grade B/C

Adults 40–75 with ≥1 CVD risk factor and 10-yr ASCVD risk ≥10%: start a statin (B). Risk 7.5–10%: selectively offer (C).

Verify at USPSTF →
ACC/AHA · 2026

New Dyslipidemia Guideline: use PREVENT (not Pooled Cohort Equations) to estimate 10-yr ASCVD risk. Intermediate risk 5–<10%: statin recommended after shared decision; borderline 3–<5%: reasonable. Statin for adults ≥40 with diabetes, CKD stage ≥3, or HIV.

Verify at ACC/AHA →

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