Aspirin for primary prevention of cardiovascular disease
What the major U.S. guidelines recommend, with a link to verify each at the source. A quick-reference summary for clinicians, not medical advice.
USPSTF · 2022 · Grade C/D
Adults 40 to 59 with 10-year CVD risk 10% or greater, no increased bleeding risk: individualize; small net benefit, shared decision (Grade C). Adults 60 or older: do not initiate aspirin for primary prevention (Grade D). Dose 81 mg/day. Net benefit shrinks with age as bleeding risk rises. Does not apply to secondary prevention. CRC benefit no longer included.
Verify at USPSTF →